8-[3-(2,4-bis-benzyloxy-5-bromo-phenyl)-1H-pyrazol-4-yl]-1,4-dioxa-8-aza-spiro[4.5]decane

Base Information

Chemical Name:8-[3-(2,4-bis-benzyloxy-5-bromo-phenyl)-1H-pyrazol-4-yl]-1,4-dioxa-8-aza-spiro[4.5]decane
CAS No.:719288-42-3
Molecular Formula:C₃₀H₃₀BrN₃O₄
Molecular Weight:576.49
Hs Code.:

Synonyms:8-[3-(2,4-bis-benzyloxy-5-bromo-phenyl)-1H-pyrazol-4-yl]-1,4-dioxa-8-aza-spiro[4.5]decane

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Chemical Property of 8-[3-(2,4-bis-benzyloxy-5-bromo-phenyl)-1H-pyrazol-4-yl]-1,4-dioxa-8-aza-spiro[4.5]decane

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Technology Process of 8-[3-(2,4-bis-benzyloxy-5-bromo-phenyl)-1H-pyrazol-4-yl]-1,4-dioxa-8-aza-spiro[4.5]decane

There total 5 articles about 8-[3-(2,4-bis-benzyloxy-5-bromo-phenyl)-1H-pyrazol-4-yl]-1,4-dioxa-8-aza-spiro[4.5]decane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 719288-41-2
1-(2,4-bis-benzyloxy-5-bromo-phenyl)-2-bromo-ethanone

: 4637-24-5
N,N-dimethyl-formamide dimethyl acetal

: 719288-42-3
8-[3-(2,4-bis-benzyloxy-5-bromo-phenyl)-1H-pyrazol-4-yl]-1,4-dioxa-8-aza-spiro[4.5]decane

Guidance literature:: 1-(2,4-bis-benzyloxy-5-bromo-phenyl)-2-bromo-ethanone; 4,4-ethylenedioxy-piperidine; With triethylamine; In DMF (N,N-dimethyl-formamide); at 20 ℃; for 1h;

N,N-dimethyl-formamide dimethyl acetal; at 110 ℃; for 16h;

With ethanol; hydrazine; more than 3 stages;

Reference yield:

: 719288-40-1
1-[2,4-bis(benzyloxy)phenyl]-2-bromoethan-1-one

: 719288-42-3
8-[3-(2,4-bis-benzyloxy-5-bromo-phenyl)-1H-pyrazol-4-yl]-1,4-dioxa-8-aza-spiro[4.5]decane

Guidance literature:: Multi-step reaction with 2 steps

1.1: N-Bromosuccinimide / DMF (N,N-dimethyl-formamide) / 18 h

2.1: triethylamine / DMF (N,N-dimethyl-formamide) / 1 h / 20 °C

2.2: 16 h / 110 °C

With N-Bromosuccinimide; triethylamine; In DMF (N,N-dimethyl-formamide);

Reference yield:

: 89-84-9
2',4'-dihydroxy-4-acetophenone

: 719288-42-3
8-[3-(2,4-bis-benzyloxy-5-bromo-phenyl)-1H-pyrazol-4-yl]-1,4-dioxa-8-aza-spiro[4.5]decane

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium carbonate / acetonitrile / 12 h

2.1: phenyl-trimethyl-ammonium perbromide / tetrahydrofuran / 2 h

3.1: N-Bromosuccinimide / DMF (N,N-dimethyl-formamide) / 18 h

4.1: triethylamine / DMF (N,N-dimethyl-formamide) / 1 h / 20 °C

4.2: 16 h / 110 °C

With N-Bromosuccinimide; phenyl-trimethyl-ammonium perbromide; potassium carbonate; triethylamine; In tetrahydrofuran; DMF (N,N-dimethyl-formamide); acetonitrile;