ethyl threo-3-(3-{[(2S,3R)-2-(4-chlorophenyl)-4,4,4-trifluoro-3-methylbutanoyl]amino}-4-fluoro-phenyl)-2-methylbutanoate

Base Information

Chemical Name:ethyl threo-3-(3-{[(2S,3R)-2-(4-chlorophenyl)-4,4,4-trifluoro-3-methylbutanoyl]amino}-4-fluoro-phenyl)-2-methylbutanoate
CAS No.:1297551-07-5
Molecular Formula:C₂₄H₂₆ClF₄NO₃
Molecular Weight:487.922
Hs Code.:

Synonyms:ethyl threo-3-(3-{[(2S,3R)-2-(4-chlorophenyl)-4,4,4-trifluoro-3-methylbutanoyl]amino}-4-fluoro-phenyl)-2-methylbutanoate

Suppliers and Price of ethyl threo-3-(3-{[(2S,3R)-2-(4-chlorophenyl)-4,4,4-trifluoro-3-methylbutanoyl]amino}-4-fluoro-phenyl)-2-methylbutanoate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of ethyl threo-3-(3-{[(2S,3R)-2-(4-chlorophenyl)-4,4,4-trifluoro-3-methylbutanoyl]amino}-4-fluoro-phenyl)-2-methylbutanoate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of ethyl threo-3-(3-{[(2S,3R)-2-(4-chlorophenyl)-4,4,4-trifluoro-3-methylbutanoyl]amino}-4-fluoro-phenyl)-2-methylbutanoate

There total 5 articles about ethyl threo-3-(3-{[(2S,3R)-2-(4-chlorophenyl)-4,4,4-trifluoro-3-methylbutanoyl]amino}-4-fluoro-phenyl)-2-methylbutanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.0%

: 1297550-14-1
(+)-(2S,3R)-2-(4-chlorophenyl)-4,4,4-trifluoro-3-methylbutanoic acid

: rac-threo-ethyl 3-(3-amino-4-fluorophenyl)-2-methylbutanoate

: 1297551-07-5
ethyl threo-3-(3-{[(2S,3R)-2-(4-chlorophenyl)-4,4,4-trifluoro-3-methylbutanoyl]amino}-4-fluoro-phenyl)-2-methylbutanoate

Guidance literature:: (+)-(2S,3R)-2-(4-chlorophenyl)-4,4,4-trifluoro-3-methylbutanoic acid; With pyridine; HATU; In N,N-dimethyl-formamide; at 20 ℃; for 0.5h;

rac-threo-ethyl 3-(3-amino-4-fluorophenyl)-2-methylbutanoate; In N,N-dimethyl-formamide; at 20 ℃;

Reference yield: 24.0%

: 1297550-14-1
(+)-(2S,3R)-2-(4-chlorophenyl)-4,4,4-trifluoro-3-methylbutanoic acid

: rac-erythro-ethyl 3-(3-amino-4-fluorophenyl)-2-methylbutanoate

: 1297551-07-5
ethyl erythro-3-(3-{[(2S,3R)-2-(4-chlorophenyl)-4,4,4-trifluoro-3-methylbutanoyl]amino}-4-fluoro-phenyl)-2-methylbutanoate

Guidance literature:: (+)-(2S,3R)-2-(4-chlorophenyl)-4,4,4-trifluoro-3-methylbutanoic acid; With pyridine; HATU; In N,N-dimethyl-formamide; at 20 ℃; for 0.5h;

rac-erythro-ethyl 3-(3-amino-4-fluorophenyl)-2-methylbutanoate; In N,N-dimethyl-formamide; at 20 ℃;

Reference yield:

: 2002-82-6
1-(3-amino-4-fluorophenyl)ethanone

: 1297551-07-5
ethyl erythro-3-(3-{[(2S,3R)-2-(4-chlorophenyl)-4,4,4-trifluoro-3-methylbutanoyl]amino}-4-fluoro-phenyl)-2-methylbutanoate

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydride / tetrahydrofuran; paraffin oil (nujol) / 0 °C

1.2: 20 °C / Reflux

2.1: hydrogen / palladium 10% on activated carbon / methanol / 750.08 Torr

3.1: pyridine; HATU / N,N-dimethyl-formamide / 0.5 h / 20 °C

3.2: 20 °C

With pyridine; hydrogen; sodium hydride; HATU; palladium 10% on activated carbon; In tetrahydrofuran; methanol; paraffin oil (nujol); N,N-dimethyl-formamide;