1-(5-tert-butylisoxazol-3-yl)-3-[3-(7-ethoxy-6-methoxyquinazolin-4-yloxy)phenyl]urea

Base Information

• Chemical Name: 1-(5-tert-butylisoxazol-3-yl)-3-[3-(7-ethoxy-6-methoxyquinazolin-4-yloxy)phenyl]urea
• CAS No.: 1188906-64-0
• Molecular Formula: C₂₅H₂₇N₅O₅
• Molecular Weight: 477.52
• Mol file: 1188906-64-0.mol

Synonyms:1-(5-tert-butylisoxazol-3-yl)-3-[3-(7-ethoxy-6-methoxyquinazolin-4-yloxy)phenyl]urea

Chemical Property of 1-(5-tert-butylisoxazol-3-yl)-3-[3-(7-ethoxy-6-methoxyquinazolin-4-yloxy)phenyl]urea

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-(5-tert-butylisoxazol-3-yl)-3-[3-(7-ethoxy-6-methoxyquinazolin-4-yloxy)phenyl]urea

There total 11 articles about 1-(5-tert-butylisoxazol-3-yl)-3-[3-(7-ethoxy-6-methoxyquinazolin-4-yloxy)phenyl]urea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-(5-tert-butylisoxazol-3-yl)-3-(3-hydroxyphenyl)urea (1188906-55-9) + 4-chloro-7-ethoxy-6-methoxy-quinazoline (643084-72-4) → 1-(5-tert-butylisoxazol-3-yl)-3-[3-(7-ethoxy-6-methoxyquinazolin-4-yloxy)phenyl]urea (1188906-64-0)

Guidance literature:

With potassium tert-butylate; In tetrahydrofuran; at 20 - 60 ℃;

Reference yield:

4-ethoxy-5-methoxy-2-nitrobenzoic acid methyl ester (214476-04-7) → 1-(5-tert-butylisoxazol-3-yl)-3-[3-(7-ethoxy-6-methoxyquinazolin-4-yloxy)phenyl]urea (1188906-64-0)

Guidance literature:

Multi-step reaction with 5 steps

1: methanol; sodium dithionite; water / 55 °C

2: acetic acid / 130 °C

3: trichlorophosphate / 110 - 115 °C

4: caesium carbonate / tetrahydrofuran / 25 h / 75 °C

5: N,N-dimethyl-formamide / 60 °C

With methanol; sodium dithionite; water; caesium carbonate; acetic acid; trichlorophosphate; In tetrahydrofuran; N,N-dimethyl-formamide;

DOI:10.1016/j.bmcl.2011.07.019

Reference yield:

4-hydroxy-3-methoxybenzoic acid methyl ester (3943-74-6) → 1-(5-tert-butylisoxazol-3-yl)-3-[3-(7-ethoxy-6-methoxyquinazolin-4-yloxy)phenyl]urea (1188906-64-0)

Guidance literature:

Multi-step reaction with 6 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 2 h / 70 °C

2.1: nitric acid; acetic anhydride / acetic acid / 20 - 50 °C

3.1: hydrogen / palladium 10% on activated carbon / methanol / 6 h / 20 °C / 760.05 Torr

4.1: formamide / 8 h / 130 °C

5.1: trichlorophosphate / toluene / 5 h / 125 °C

5.2: Saturated solution

6.1: potassium tert-butylate / tetrahydrofuran / 20 - 60 °C

With potassium tert-butylate; hydrogen; nitric acid; acetic anhydride; potassium carbonate; trichlorophosphate; palladium 10% on activated carbon; In tetrahydrofuran; methanol; formamide; acetic acid; N,N-dimethyl-formamide; toluene;

upstream raw materials:

1-(5-tert-butylisoxazol-3-yl)-3-(3-hydroxyphenyl)urea

4-chloro-7-ethoxy-6-methoxy-quinazoline

phenyl (5-(tert-butyl)isoxazol-3-yl)carbamate

C₁₇H₁₇N₃O₃