dibenzyl 3,6-dimethylpyrazine-2,5-dicarboxylate

Base Information

• Chemical Name: dibenzyl 3,6-dimethylpyrazine-2,5-dicarboxylate
• CAS No.: 102441-95-2
• Molecular Formula: C₂₂H₂₀N₂O₄
• Molecular Weight: 376.412
• Mol file: 102441-95-2.mol

Synonyms:dibenzyl 3,6-dimethylpyrazine-2,5-dicarboxylate

Chemical Property of dibenzyl 3,6-dimethylpyrazine-2,5-dicarboxylate

Chemical Property:

Purity/Quality:

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MSDS Files:

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Technology Process of dibenzyl 3,6-dimethylpyrazine-2,5-dicarboxylate

There total 4 articles about dibenzyl 3,6-dimethylpyrazine-2,5-dicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

benzyl (Z/E)-2-hydroxyimino-3-oxobutanoate (27331-98-2) → dibenzyl 3,6-dimethylpyrazine-2,5-dicarboxylate (102441-95-2)

Guidance literature:

With NADPH; In aq. phosphate buffer; dimethyl sulfoxide; at 30 ℃; for 24h; pH=7.5; Reagent/catalyst; Enzymatic reaction;

DOI:10.1021/acscatal.0c03755

Reference yield: 37.0%

benzyl 2-(methoxyimino)-3-oxobutanoate → dibenzyl 3,6-dimethylpyrazine-2,5-dicarboxylate (102441-95-2)

Guidance literature:

With Sucrose; In ethanol; water; at 30 ℃; for 144h; pH=5; chemoselective reaction; Enzymatic reaction;

DOI:10.1016/j.molcatb.2015.11.003

Reference yield: 25.0%

methyl 4-acetyl-5-oxohexanoate (13984-53-7) + benzyl acetoacetate (5396-89-4) → dibenzyl 3,6-dimethylpyrazine-2,5-dicarboxylate (102441-95-2) + benzyl 4-<(methoxycarbonyl)methyl>-3,5-dimethylpyrrole-2-carboxylate (31837-62-4)

Guidance literature:

methyl 4-acetyl-5-oxohexanoate; benzyl acetoacetate; With acetic acid; sodium nitrite; In water; for 1h;

With zinc; In water; at 50 ℃; for 2h; Further stages.;

DOI:10.1007/s10870-007-9307-5

upstream raw materials:

2-amino-acetoacetic acid benzyl ester; hydrochloride

methyl 4-acetyl-5-oxohexanoate

benzyl acetoacetate

benzyl (Z/E)-2-hydroxyimino-3-oxobutanoate