C₃₆H₃₈O₁₀

Base Information

• Chemical Name: C₃₆H₃₈O₁₀
• CAS No.: 1415692-77-1
• Molecular Formula: C₃₆H₃₈O₁₀
• Molecular Weight: 630.692
• Mol file: 1415692-77-1.mol

Synonyms:C₃₆H₃₈O₁₀

Chemical Property of C₃₆H₃₈O₁₀

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₃₆H₃₈O₁₀

There total 5 articles about C₃₆H₃₈O₁₀ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

(1S,3′R,4′S,5′S,6′R)-3′,4′,5′-tri(acetoxy)-6′-acetoxymethyl-5-chloro-6-[(4-ethylphenyl)methyl]-3′,4′,5′,6′-tetrahydrospiro-[isobenzofuran-1(3H),2′-[2H]pyran] (1005142-67-5) + phenylboronic acid (98-80-6) → C36H38O10 (1415692-77-1)

Guidance literature:

With potassium fluoride; monophosphine 1,2,3,4,5-pentaphenyl-1'-(di-tert-butylphosphino)ferrocene; bis(dibenzylideneacetone)-palladium⁽⁰⁾; In tetrahydrofuran; at 100 ℃; for 0.5h; Microwave irradiation;

DOI:10.1021/jm300884k

Reference yield:

[4-(acetoxymethyl)-2-bromo-5-chlorophenyl]methyl acetate (1005142-57-3) → C36H38O10 (1415692-77-1)

Guidance literature:

Multi-step reaction with 7 steps

1.1: potassium hydroxide; water / tetrahydrofuran; ethanol / 3 h / 80 °C

2.1: pyridinium p-toluenesulfonate / tetrahydrofuran / 2 h / 0 °C

3.1: n-butyllithium / tetrahydrofuran; hexane / 0.42 h / -78 °C / Inert atmosphere

3.2: 0.08 h

4.1: toluene-4-sulfonic acid / tetrahydrofuran; methanol / 15 h / 20 °C

5.1: chloro-trimethyl-silane / dimethyl sulfoxide / 4 h / 20 °C

5.2: 1 h / 0 - 20 °C

6.1: tetrabutylammomium bromide; bis(cyclopentadienyl)titanium dichloride; sodium carbonate / water; N,N-dimethyl-formamide / 15 h / 85 °C

7.1: bis(dibenzylideneacetone)-palladium⁽⁰⁾; monophosphine 1,2,3,4,5-pentaphenyl-1'-(di-tert-butylphosphino)ferrocene; potassium fluoride / tetrahydrofuran / 0.5 h / 100 °C / Microwave irradiation

With bis(cyclopentadienyl)titanium dichloride; potassium fluoride; n-butyllithium; chloro-trimethyl-silane; monophosphine 1,2,3,4,5-pentaphenyl-1'-(di-tert-butylphosphino)ferrocene; tetrabutylammomium bromide; water; pyridinium p-toluenesulfonate; sodium carbonate; toluene-4-sulfonic acid; potassium hydroxide; bis(dibenzylideneacetone)-palladium⁽⁰⁾; In tetrahydrofuran; methanol; ethanol; hexane; water; dimethyl sulfoxide; N,N-dimethyl-formamide;

DOI:10.1021/jm300884k

Reference yield:

1-bromo-4-chloro-2,5-dimethylbenzene (85072-44-2) → C36H38O10 (1415692-77-1)

Guidance literature:

Multi-step reaction with 9 steps

1.1: N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile) / ethyl acetate / 0.33 h / Reflux

2.1: N,N-dimethyl-formamide / 3 h / 80 °C

3.1: potassium hydroxide; water / tetrahydrofuran; ethanol / 3 h / 80 °C

4.1: pyridinium p-toluenesulfonate / tetrahydrofuran / 2 h / 0 °C

5.1: n-butyllithium / tetrahydrofuran; hexane / 0.42 h / -78 °C / Inert atmosphere

5.2: 0.08 h

6.1: toluene-4-sulfonic acid / tetrahydrofuran; methanol / 15 h / 20 °C

7.1: chloro-trimethyl-silane / dimethyl sulfoxide / 4 h / 20 °C

7.2: 1 h / 0 - 20 °C

8.1: tetrabutylammomium bromide; bis(cyclopentadienyl)titanium dichloride; sodium carbonate / water; N,N-dimethyl-formamide / 15 h / 85 °C

9.1: bis(dibenzylideneacetone)-palladium⁽⁰⁾; monophosphine 1,2,3,4,5-pentaphenyl-1'-(di-tert-butylphosphino)ferrocene; potassium fluoride / tetrahydrofuran / 0.5 h / 100 °C / Microwave irradiation

With bis(cyclopentadienyl)titanium dichloride; potassium fluoride; N-Bromosuccinimide; n-butyllithium; chloro-trimethyl-silane; monophosphine 1,2,3,4,5-pentaphenyl-1'-(di-tert-butylphosphino)ferrocene; 2,2'-azobis(isobutyronitrile); tetrabutylammomium bromide; water; pyridinium p-toluenesulfonate; sodium carbonate; toluene-4-sulfonic acid; potassium hydroxide; bis(dibenzylideneacetone)-palladium⁽⁰⁾; In tetrahydrofuran; methanol; ethanol; hexane; water; dimethyl sulfoxide; ethyl acetate; N,N-dimethyl-formamide;

DOI:10.1021/jm300884k

upstream raw materials:

(1S,3′R,4′S,5′S,6′R)-3′,4′,5′-tri(acetoxy)-6′-acetoxymethyl-5-chloro-6-[(4-ethylphenyl)methyl]-3′,4′,5′,6′-tetrahydrospiro-[isobenzofuran-1(3H),2′-[2H]pyran]

phenylboronic acid

1-bromo-4-chloro-2,5-dimethylbenzene

1-bromo-2,5-bis(bromomethyl)-4-chlorobenzene

Downstream raw materials:

C₂₈H₃₀O₆