3-[trans-2-(2-methoxyphenyl)vinyl]-5-(2-methoxy-(1S)-methyl-ethoxy)-N-(nicotinic acid-6-yl)-benzamide

Base Information

Chemical Name:3-[trans-2-(2-methoxyphenyl)vinyl]-5-(2-methoxy-(1S)-methyl-ethoxy)-N-(nicotinic acid-6-yl)-benzamide
CAS No.:1282520-04-0
Molecular Formula:C₂₆H₂₆N₂O₆
Molecular Weight:462.502
Hs Code.:

Synonyms:3-[trans-2-(2-methoxyphenyl)vinyl]-5-(2-methoxy-(1S)-methyl-ethoxy)-N-(nicotinic acid-6-yl)-benzamide

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Chemical Property of 3-[trans-2-(2-methoxyphenyl)vinyl]-5-(2-methoxy-(1S)-methyl-ethoxy)-N-(nicotinic acid-6-yl)-benzamide

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Technology Process of 3-[trans-2-(2-methoxyphenyl)vinyl]-5-(2-methoxy-(1S)-methyl-ethoxy)-N-(nicotinic acid-6-yl)-benzamide

There total 11 articles about 3-[trans-2-(2-methoxyphenyl)vinyl]-5-(2-methoxy-(1S)-methyl-ethoxy)-N-(nicotinic acid-6-yl)-benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.7%

: 1282519-84-9
3-[trans-2-(2-methoxyphenyl)vinyl]-5-(2-methoxy-(1S)-methyl-ethoxy)-N-(nicotinic acid-3-methyl ester-6-yl)-benzamide

: 1282520-04-0
3-[trans-2-(2-methoxyphenyl)vinyl]-5-(2-methoxy-(1S)-methyl-ethoxy)-N-(nicotinic acid-6-yl)-benzamide

Guidance literature:: 3-[trans-2-(2-methoxyphenyl)vinyl]-5-(2-methoxy-(1S)-methyl-ethoxy)-N-(nicotinic acid-3-methyl ester-6-yl)-benzamide; With sodium hydroxide; In tetrahydrofuran; at 20 ℃; for 12h;

With hydrogenchloride; In water;

Reference yield:

: 1282520-90-4
5-(2-methoxy-(1S)-methyl-ethoxy)isophthalic acid monomethyl ester

: 1282520-04-0
3-[trans-2-(2-methoxyphenyl)vinyl]-5-(2-methoxy-(1S)-methyl-ethoxy)-N-(nicotinic acid-6-yl)-benzamide

Guidance literature:: Multi-step reaction with 8 steps

1.1: borane-THF / tetrahydrofuran / 12 h / 0 - 20 °C

1.2: 3 h / 0 °C

2.1: sodium hydroxide / tetrahydrofuran / 12 h / 20 °C

3.1: pyridine / dichloromethane / 2 h / 0 - 20 °C

4.1: thionyl chloride / 3 h / 100 °C

4.2: 12 h / 20 °C

5.1: potassium carbonate / water; methanol / 2 h / 20 °C

5.2: 12 h / 0 - 20 °C

6.1: 3 h / 160 °C

7.1: potassium tert-butylate / tetrahydrofuran / 12 h / 20 °C

8.1: sodium hydroxide / tetrahydrofuran / 12 h / 20 °C

With pyridine; thionyl chloride; borane-THF; potassium tert-butylate; potassium carbonate; sodium hydroxide; In tetrahydrofuran; methanol; dichloromethane; water;

Reference yield:

: 13036-02-7
Dimethyl 5-hydroxyisophthalate

: 1282520-04-0
3-[trans-2-(2-methoxyphenyl)vinyl]-5-(2-methoxy-(1S)-methyl-ethoxy)-N-(nicotinic acid-6-yl)-benzamide

Guidance literature:: Multi-step reaction with 10 steps

1.1: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 12 h / 0 - 20 °C

2.1: potassium hydroxide; methanol / 12 h / 100 °C

3.1: borane-THF / tetrahydrofuran / 12 h / 0 - 20 °C

3.2: 3 h / 0 °C

4.1: sodium hydroxide / tetrahydrofuran / 12 h / 20 °C

5.1: pyridine / dichloromethane / 2 h / 0 - 20 °C

6.1: thionyl chloride / 3 h / 100 °C

6.2: 12 h / 20 °C

7.1: potassium carbonate / water; methanol / 2 h / 20 °C

7.2: 12 h / 0 - 20 °C

8.1: 3 h / 160 °C

9.1: potassium tert-butylate / tetrahydrofuran / 12 h / 20 °C

10.1: sodium hydroxide / tetrahydrofuran / 12 h / 20 °C

With pyridine; methanol; thionyl chloride; borane-THF; di-isopropyl azodicarboxylate; potassium tert-butylate; potassium carbonate; triphenylphosphine; potassium hydroxide; sodium hydroxide; In tetrahydrofuran; methanol; dichloromethane; water;