2,4-dichloro-N-((1-(4-(propylsulfonyl)piperazin-1-yl)cyclohexyl)methyl)benzamide

Base Information

Chemical Name:2,4-dichloro-N-((1-(4-(propylsulfonyl)piperazin-1-yl)cyclohexyl)methyl)benzamide
CAS No.:1351673-75-0
Molecular Formula:C₂₁H₃₁Cl₂N₃O₃S
Molecular Weight:476.467
Hs Code.:

Synonyms:2,4-dichloro-N-((1-(4-(propylsulfonyl)piperazin-1-yl)cyclohexyl)methyl)benzamide

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Chemical Property of 2,4-dichloro-N-((1-(4-(propylsulfonyl)piperazin-1-yl)cyclohexyl)methyl)benzamide

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Technology Process of 2,4-dichloro-N-((1-(4-(propylsulfonyl)piperazin-1-yl)cyclohexyl)methyl)benzamide

There total 7 articles about 2,4-dichloro-N-((1-(4-(propylsulfonyl)piperazin-1-yl)cyclohexyl)methyl)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.0%

: 1351676-44-2
(1-(4-(propylsulfonyl)piperazin-1-yl)cyclohexyl)methanamine

: 89-75-8
2,4-dichlorobenzoyl chloride

: 1351673-75-0
2,4-dichloro-N-((1-(4-(propylsulfonyl)piperazin-1-yl)cyclohexyl)methyl)benzamide

Guidance literature:: With triethylamine; In dichloromethane; at 25 ℃; for 16h; Inert atmosphere;
DOI:10.1021/acs.jmedchem.6b00914

Reference yield:

: 139754-93-1
1-(4-benzylpiperazin-1-yl)cyclohexanecarbonitrile

: 1351673-75-0
2,4-dichloro-N-((1-(4-(propylsulfonyl)piperazin-1-yl)cyclohexyl)methyl)benzamide

Guidance literature:: Multi-step reaction with 6 steps

1: lithium aluminium tetrahydride / diethyl ether / 12.5 h / Inert atmosphere; Cooling

2: triethylamine / dichloromethane / 16 h / 25 °C / Inert atmosphere

3: palladium 10% on activated carbon; ammonium formate / methanol / 3 h / Heating; Inert atmosphere

4: triethylamine / dichloromethane / 1 h / 25 °C / Inert atmosphere

5: water; potassium carbonate / methanol / 16 h / Inert atmosphere; Reflux

6: triethylamine / dichloromethane / 16 h / 25 °C / Inert atmosphere

With lithium aluminium tetrahydride; palladium 10% on activated carbon; water; ammonium formate; potassium carbonate; triethylamine; In methanol; diethyl ether; dichloromethane;
DOI:10.1021/acs.jmedchem.6b00914

Reference yield:

: 511538-96-8
(1-(4-benzylpiperazin-1-yl)cyclohexyl)methanamine

: 1351673-75-0
2,4-dichloro-N-((1-(4-(propylsulfonyl)piperazin-1-yl)cyclohexyl)methyl)benzamide

Guidance literature:: Multi-step reaction with 5 steps

1: triethylamine / dichloromethane / 16 h / 25 °C / Inert atmosphere

2: palladium 10% on activated carbon; ammonium formate / methanol / 3 h / Heating; Inert atmosphere

3: triethylamine / dichloromethane / 1 h / 25 °C / Inert atmosphere

4: water; potassium carbonate / methanol / 16 h / Inert atmosphere; Reflux

5: triethylamine / dichloromethane / 16 h / 25 °C / Inert atmosphere

With palladium 10% on activated carbon; water; ammonium formate; potassium carbonate; triethylamine; In methanol; dichloromethane;
DOI:10.1021/acs.jmedchem.6b00914