Technology Process of 6R-(5-cyclopropyl-3S-hydroxy-pent-1E-enyl)-1-(2-hydroxyethyl)-piperidin-2-one
There total 1 articles about 6R-(5-cyclopropyl-3S-hydroxy-pent-1E-enyl)-1-(2-hydroxyethyl)-piperidin-2-one which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
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Multi-step reaction with 8 steps
1.1: NaH; KI / dimethylformamide
2.1: aq. K2CO3 / methanol
3.1: i-BuCOCl
3.2: NaBH4 / 0 - 20 °C
4.1: LiCl; i-Pr2NEt
5.1: (R)-2-methyl-CBS; BH3*SMe2 / 0.33 h / 0 °C
6.1: tetrabutylammonium fluoride / tetrahydrofuran / 3 h / 20 °C
With
dimethylsulfide borane complex; tetrabutyl ammonium fluoride; sodium hydride; potassium carbonate; N-ethyl-N,N-diisopropylamine; isopentanoyl chloride; potassium iodide; lithium chloride; (3aR)-1-methyl-3,3-diphenyl-tetrahydro-pyrrolo[1,2-c][1,3,2]oxazaborole;
In
tetrahydrofuran; methanol; N,N-dimethyl-formamide;
5.1: Swern oxidation;
DOI:10.1016/j.bmcl.2005.03.059
