ethyl (E)-3-<1-ethyl-6-methoxy-7-(methoxymethoxy)-3-methyl-2-phenylindole-4-yl>-2-methylpropenoate

Base Information

Chemical Name:ethyl (E)-3-<1-ethyl-6-methoxy-7-(methoxymethoxy)-3-methyl-2-phenylindole-4-yl>-2-methylpropenoate
CAS No.:1026010-13-8
Molecular Formula:C₂₆H₃₁NO₅
Molecular Weight:437.536
Hs Code.:

Synonyms:ethyl (E)-3-<1-ethyl-6-methoxy-7-(methoxymethoxy)-3-methyl-2-phenylindole-4-yl>-2-methylpropenoate

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Chemical Property of ethyl (E)-3-<1-ethyl-6-methoxy-7-(methoxymethoxy)-3-methyl-2-phenylindole-4-yl>-2-methylpropenoate

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Technology Process of ethyl (E)-3-<1-ethyl-6-methoxy-7-(methoxymethoxy)-3-methyl-2-phenylindole-4-yl>-2-methylpropenoate

There total 11 articles about ethyl (E)-3-<1-ethyl-6-methoxy-7-(methoxymethoxy)-3-methyl-2-phenylindole-4-yl>-2-methylpropenoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 90-04-0
2-methoxy-phenylamine

: 1026010-13-8
ethyl (E)-3-<1-ethyl-6-methoxy-7-(methoxymethoxy)-3-methyl-2-phenylindole-4-yl>-2-methylpropenoate

Guidance literature:: Multi-step reaction with 10 steps

1: 87 percent / 2-methoxy-ethanol; various solvent(s) / 1.5 h / 80 - 130 °C

2: 1.) NaH / 1.) DMF, 0 deg C, 2.) DMF, RT, 30 min

3: BBr₃ / CH₂Cl₂ / 1 h / Ambient temperature

4: 1.) NaH / 1.) DMF, 0 deg C, 2.) DMF, RT, 30 min

5: 1.) n-BuLi / 1.) hexane, Et₂O, RT, 2 h, 2.) hexane, Et₂O, RT, 30 min

6: H₂O₂, KHSO₄ / methanol / 2 h / Ambient temperature

7: 1.) NaH / 1.) DMF, 0 deg C, 2.) DMF, RT, 30 min

8: POCl₃ / 12 h / Ambient temperature

9: 1.) NaH / 1.) DMF, 0 deg C, 2.) DMF, RT, 30 min

10: 1.) NaH / 1.) DMF, 0 deg C, 10 min, 2.) DMF, RT, 2 h

With potassium hydrogensulfate; n-butyllithium; dihydrogen peroxide; boron tribromide; sodium hydride; trichlorophosphate; In methanol; dichloromethane; 2-methoxy-ethanol;
DOI:10.1016/0223-5234(96)89134-3

Reference yield:

: 2114-00-3
2-bromo-1-phenyl-1-propanone

: 1026010-13-8
ethyl (E)-3-<1-ethyl-6-methoxy-7-(methoxymethoxy)-3-methyl-2-phenylindole-4-yl>-2-methylpropenoate

Guidance literature:: Multi-step reaction with 10 steps

1: 87 percent / 2-methoxy-ethanol; various solvent(s) / 1.5 h / 80 - 130 °C

2: 1.) NaH / 1.) DMF, 0 deg C, 2.) DMF, RT, 30 min

3: BBr₃ / CH₂Cl₂ / 1 h / Ambient temperature

4: 1.) NaH / 1.) DMF, 0 deg C, 2.) DMF, RT, 30 min

5: 1.) n-BuLi / 1.) hexane, Et₂O, RT, 2 h, 2.) hexane, Et₂O, RT, 30 min

6: H₂O₂, KHSO₄ / methanol / 2 h / Ambient temperature

7: 1.) NaH / 1.) DMF, 0 deg C, 2.) DMF, RT, 30 min

8: POCl₃ / 12 h / Ambient temperature

9: 1.) NaH / 1.) DMF, 0 deg C, 2.) DMF, RT, 30 min

10: 1.) NaH / 1.) DMF, 0 deg C, 10 min, 2.) DMF, RT, 2 h

With potassium hydrogensulfate; n-butyllithium; dihydrogen peroxide; boron tribromide; sodium hydride; trichlorophosphate; In methanol; dichloromethane; 2-methoxy-ethanol;
DOI:10.1016/0223-5234(96)89134-3

Reference yield:

: 176963-03-4
7-methoxy-3-methyl-2-phenylindole

: 1026010-13-8
ethyl (E)-3-<1-ethyl-6-methoxy-7-(methoxymethoxy)-3-methyl-2-phenylindole-4-yl>-2-methylpropenoate

Guidance literature:: Multi-step reaction with 9 steps

1: 1.) NaH / 1.) DMF, 0 deg C, 2.) DMF, RT, 30 min

2: BBr₃ / CH₂Cl₂ / 1 h / Ambient temperature

3: 1.) NaH / 1.) DMF, 0 deg C, 2.) DMF, RT, 30 min

4: 1.) n-BuLi / 1.) hexane, Et₂O, RT, 2 h, 2.) hexane, Et₂O, RT, 30 min

5: H₂O₂, KHSO₄ / methanol / 2 h / Ambient temperature

6: 1.) NaH / 1.) DMF, 0 deg C, 2.) DMF, RT, 30 min

7: POCl₃ / 12 h / Ambient temperature

8: 1.) NaH / 1.) DMF, 0 deg C, 2.) DMF, RT, 30 min

9: 1.) NaH / 1.) DMF, 0 deg C, 10 min, 2.) DMF, RT, 2 h

With potassium hydrogensulfate; n-butyllithium; dihydrogen peroxide; boron tribromide; sodium hydride; trichlorophosphate; In methanol; dichloromethane;
DOI:10.1016/0223-5234(96)89134-3