2-Pyridinecarboxylicacid,5-cyano-,methylester(9CI)

Base Information

• Chemical Name: 2-Pyridinecarboxylicacid,5-cyano-,methylester(9CI)
• CAS No.: 76196-66-2
• Molecular Formula: C8H6 N2 O2
• Molecular Weight: 162.148
• Hs Code.: 2933399090
• Mol file: 76196-66-2.mol

Synonyms:Methyl5-cyanopyridine-2-carboxylate

Chemical Property of 2-Pyridinecarboxylicacid,5-cyano-,methylester(9CI)

Chemical Property:

• Boiling Point: 323.6±27.0 °C(Predicted)
• PKA: -1.75±0.10(Predicted)
• PSA: 62.98000
• Density: 1.25±0.1 g/cm3(Predicted)
• LogP: 0.73988
• Storage Temp.: 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

Methyl 5-cyanopyridine-2-carboxylate 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Pyridinecarboxylicacid,5-cyano-,methylester(9CI)

There total 4 articles about 2-Pyridinecarboxylicacid,5-cyano-,methylester(9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

potassium hexacyanoferrate(II) trihydrate + methyl 5-bromopicolinate (29682-15-3) → Methyl 5-cyanopyridine-2-carboxylate (76196-66-2)

Guidance literature:

With dichloro(2,2-bis(diphenylphosphino)diphenyl ether)palladium(II); potassium acetate; In 1,4-dioxane; water; at 90 ℃; for 1.33333h; Temperature; Sealed tube;

DOI:10.1021/acs.joc.8b00515

Reference yield: 75.0%

potassium cyanide + methyl 5-bromopicolinate (29682-15-3) → Methyl 5-cyanopyridine-2-carboxylate (76196-66-2)

Guidance literature:

potassium cyanide; With acetic acid; In ethylene glycol; at 20 ℃; Sealed tube;

methyl 5-bromopicolinate; With P(t-Bu)3 Palladacycle Gen_. 3; potassium acetate; In 1,4-dioxane; water; at 60 ℃; for 16h; Sealed tube;

DOI:10.1039/c7sc03912c

Reference yield: 36.0%

copper(l) cyanide + methyl 5-bromopicolinate (29682-15-3) → Methyl 5-cyanopyridine-2-carboxylate (76196-66-2)

Guidance literature:

In 1-methyl-pyrrolidin-2-one; at 170 ℃; for 3h; Concentration;

upstream raw materials:

methyl 5-bromopicolinate

Downstream raw materials:

5-(aminomethyl)pyridine-2-carboxylic acid