Acetic acid 2-(7-hydroxy-6,6,8-trimethyl-1,4-dioxa-spiro[4.5]dec-7-ylethynyl)-3,5-dimethoxy-benzyl ester

Base Information

• Chemical Name: Acetic acid 2-(7-hydroxy-6,6,8-trimethyl-1,4-dioxa-spiro[4.5]dec-7-ylethynyl)-3,5-dimethoxy-benzyl ester
• CAS No.: 153786-84-6
• Molecular Formula: C₂₄H₃₂O₇
• Molecular Weight: 432.514
• Mol file: 153786-84-6.mol

Synonyms:Acetic acid 2-(7-hydroxy-6,6,8-trimethyl-1,4-dioxa-spiro[4.5]dec-7-ylethynyl)-3,5-dimethoxy-benzyl ester

Chemical Property of Acetic acid 2-(7-hydroxy-6,6,8-trimethyl-1,4-dioxa-spiro[4.5]dec-7-ylethynyl)-3,5-dimethoxy-benzyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Acetic acid 2-(7-hydroxy-6,6,8-trimethyl-1,4-dioxa-spiro[4.5]dec-7-ylethynyl)-3,5-dimethoxy-benzyl ester

There total 4 articles about Acetic acid 2-(7-hydroxy-6,6,8-trimethyl-1,4-dioxa-spiro[4.5]dec-7-ylethynyl)-3,5-dimethoxy-benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

7-Ethynyl-6,6,8-trimethyl-1,4-dioxa-spiro[4.5]decan-7-ol (153786-92-6) + 2-iodo-3,5-dimethoxybenzyl acetate (153786-93-7) → Acetic acid 2-(7-hydroxy-6,6,8-trimethyl-1,4-dioxa-spiro[4.5]dec-7-ylethynyl)-3,5-dimethoxy-benzyl ester (153786-84-6)

Guidance literature:

With palladium diacetate; triethylamine; triphenylphosphine; for 3.5h; Heating;

DOI:10.1021/jo951935e

Reference yield:

3,5-dimethoxybenzyl alcohol (705-76-0) → Acetic acid 2-(7-hydroxy-6,6,8-trimethyl-1,4-dioxa-spiro[4.5]dec-7-ylethynyl)-3,5-dimethoxy-benzyl ester (153786-84-6)

Guidance literature:

Multi-step reaction with 3 steps

1: 93 percent / pyridine / CH₂Cl₂

2: 94 percent / iodine, acetic acid, aq. H₂O₂ / 6.5 h

3: 85 percent / Et₃N, Pd(OAc)2, PPh₃ / 3.5 h / Heating

With pyridine; palladium diacetate; dihydrogen peroxide; iodine; acetic acid; triethylamine; triphenylphosphine; In dichloromethane;

DOI:10.1021/jo951935e

Reference yield:

3,3-(ethylenedioxy)-2,2,6-trimethyl-1-cyclohexanone (114198-58-2) → Acetic acid 2-(7-hydroxy-6,6,8-trimethyl-1,4-dioxa-spiro[4.5]dec-7-ylethynyl)-3,5-dimethoxy-benzyl ester (153786-84-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 87 percent / tetrahydrofuran / 48 h / Ambient temperature

2: 85 percent / Et₃N, Pd(OAc)2, PPh₃ / 3.5 h / Heating

With palladium diacetate; triethylamine; triphenylphosphine; In tetrahydrofuran;

DOI:10.1021/jo951935e

upstream raw materials:

7-Ethynyl-6,6,8-trimethyl-1,4-dioxa-spiro[4.5]decan-7-ol

2-iodo-3,5-dimethoxybenzyl acetate

3,5-dimethoxybenzyl alcohol

3,3-(ethylenedioxy)-2,2,6-trimethyl-1-cyclohexanone

Downstream raw materials:

Acetic acid 3,5-dimethoxy-2-[(E)-2-(6,6,8-trimethyl-1,4-dioxa-spiro[4.5]dec-7-en-7-yl)-vinyl]-benzyl ester

Acetic acid 3,5-dimethoxy-2-[(Z)-2-(6,6,8-trimethyl-1,4-dioxa-spiro[4.5]dec-7-en-7-yl)-vinyl]-benzyl ester

3-(2-Hydroxymethyl-4,6-dimethoxy-phenylethynyl)-2,2,4-trimethyl-cyclohex-3-enone

3-[(Z)-2-(2-Hydroxymethyl-4,6-dimethoxy-phenyl)-vinyl]-2,2,4-trimethyl-cyclohex-3-enol