2-((2S,3S,4R)-1-(4-(((3,4-trans)-1-(5-chloro-2-methoxypyridin-4-yl)-3-methylpiperidin-4-yl)oxy)-2-fluorophenyl)-4-methoxy-3-methylpyrrolidin-2-yl)acetonitrile

Base Information

Chemical Name:2-((2S,3S,4R)-1-(4-(((3,4-trans)-1-(5-chloro-2-methoxypyridin-4-yl)-3-methylpiperidin-4-yl)oxy)-2-fluorophenyl)-4-methoxy-3-methylpyrrolidin-2-yl)acetonitrile
CAS No.:1610036-04-8
Molecular Formula:C₂₆H₃₂ClFN₄O₃
Molecular Weight:503.016
Hs Code.:

2-((2S,3S,4R)-1-(4-(((3,4-trans)-1-(5-chloro-2-methoxypyridin-4-yl)-3-methylpiperidin-4-yl)oxy)-2-fluorophenyl)-4-methoxy-3-methylpyrrolidin-2-yl)acetonitrile

Synonyms:2-((2S,3S,4R)-1-(4-(((3,4-trans)-1-(5-chloro-2-methoxypyridin-4-yl)-3-methylpiperidin-4-yl)oxy)-2-fluorophenyl)-4-methoxy-3-methylpyrrolidin-2-yl)acetonitrile

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Chemical Property of 2-((2S,3S,4R)-1-(4-(((3,4-trans)-1-(5-chloro-2-methoxypyridin-4-yl)-3-methylpiperidin-4-yl)oxy)-2-fluorophenyl)-4-methoxy-3-methylpyrrolidin-2-yl)acetonitrile

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Technology Process of 2-((2S,3S,4R)-1-(4-(((3,4-trans)-1-(5-chloro-2-methoxypyridin-4-yl)-3-methylpiperidin-4-yl)oxy)-2-fluorophenyl)-4-methoxy-3-methylpyrrolidin-2-yl)acetonitrile

There total 10 articles about 2-((2S,3S,4R)-1-(4-(((3,4-trans)-1-(5-chloro-2-methoxypyridin-4-yl)-3-methylpiperidin-4-yl)oxy)-2-fluorophenyl)-4-methoxy-3-methylpyrrolidin-2-yl)acetonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 59.0%

: potassium cyanide

: 1610036-03-7
((2R,3S,4R)-1-(4-(((3,4-trans)-1-(5-chloro-2-methoxypyridin-4-yl)-3-methylpiperidin-4-yl)oxy)-2-fluorophenyl)-4-methoxy-3-methylpyrrolidin-2-yl)methanol

: 1610036-04-8
2-((2S,3S,4R)-1-(4-(((3,4-trans)-1-(5-chloro-2-methoxypyridin-4-yl)-3-methylpiperidin-4-yl)oxy)-2-fluorophenyl)-4-methoxy-3-methylpyrrolidin-2-yl)acetonitrile

Guidance literature:: ((2R,3S,4R)-1-(4-(((3,4-trans)-1-(5-chloro-2-methoxypyridin-4-yl)-3-methylpiperidin-4-yl)oxy)-2-fluorophenyl)-4-methoxy-3-methylpyrrolidin-2-yl)methanol; With methanesulfonyl chloride; triethylamine; In dichloromethane; at 0 - 20 ℃; for 3.5h;

potassium cyanide; With potassium iodide; In dimethyl sulfoxide; at 65 ℃; for 5h; Inert atmosphere;

Reference yield:

: 5-chloro-4-((3,4-trans)-4-(3-fluoro-4-iodophenoxy)-3-methylpiperidin1-yl)-2-methoxypyridine

: 1610036-04-8
2-((2S,3S,4R)-1-(4-(((3,4-trans)-1-(5-chloro-2-methoxypyridin-4-yl)-3-methylpiperidin-4-yl)oxy)-2-fluorophenyl)-4-methoxy-3-methylpyrrolidin-2-yl)acetonitrile

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydroxide; copper(l) iodide / butan-1-ol / 18.5 h / 90 °C / Inert atmosphere; Irradiation

2.1: triethylamine; methanesulfonyl chloride / dichloromethane / 3.5 h / 0 - 20 °C

2.2: 5 h / 65 °C / Inert atmosphere

With copper(l) iodide; methanesulfonyl chloride; triethylamine; sodium hydroxide; In dichloromethane; butan-1-ol;

Reference yield:

: 1367552-62-2
1-benzyl 2-methyl (R)-4-((tert-butyldimethylsilyl)oxy)-4.5-dihydro-1H-pyrrole-1,2-dicarboxylate

: 1610036-04-8
2-((2S,3S,4R)-1-(4-(((3,4-trans)-1-(5-chloro-2-methoxypyridin-4-yl)-3-methylpiperidin-4-yl)oxy)-2-fluorophenyl)-4-methoxy-3-methylpyrrolidin-2-yl)acetonitrile

Guidance literature:: Multi-step reaction with 7 steps

1.1: copper(I) bromide dimethylsulfide complex / diethyl ether / 1 h

1.2: 0.75 h / -45 °C

2.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 1 h / 20 °C

3.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 0 °C

3.2: 20 °C

4.1: lithium borohydride / tetrahydrofuran / 0 - 20 °C

5.1: palladium 10% on activated carbon; hydrogen / methanol / 2 h / 20 °C / 760.05 Torr / Inert atmosphere

6.1: sodium hydroxide; copper(l) iodide / butan-1-ol / 18.5 h / 90 °C / Inert atmosphere; Irradiation

7.1: triethylamine; methanesulfonyl chloride / dichloromethane / 3.5 h / 0 - 20 °C

7.2: 5 h / 65 °C / Inert atmosphere

With copper(l) iodide; lithium borohydride; copper(I) bromide dimethylsulfide complex; palladium 10% on activated carbon; tetrabutyl ammonium fluoride; hydrogen; sodium hydride; methanesulfonyl chloride; triethylamine; sodium hydroxide; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; N,N-dimethyl-formamide; mineral oil; butan-1-ol;