[2-((S)-2-Hydroxymethyl-4-oxo-pyrrolidine-1-carbonyl)-4,5-dimethoxy-phenyl]-carbamic acid 2,2,2-trichloro-ethyl ester

Base Information

Chemical Name:[2-((S)-2-Hydroxymethyl-4-oxo-pyrrolidine-1-carbonyl)-4,5-dimethoxy-phenyl]-carbamic acid 2,2,2-trichloro-ethyl ester
CAS No.:689284-03-5
Molecular Formula:C₁₇H₁₉Cl₃N₂O₇
Molecular Weight:469.706
Hs Code.:

Synonyms:[2-((S)-2-Hydroxymethyl-4-oxo-pyrrolidine-1-carbonyl)-4,5-dimethoxy-phenyl]-carbamic acid 2,2,2-trichloro-ethyl ester

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Chemical Property of [2-((S)-2-Hydroxymethyl-4-oxo-pyrrolidine-1-carbonyl)-4,5-dimethoxy-phenyl]-carbamic acid 2,2,2-trichloro-ethyl ester

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Technology Process of [2-((S)-2-Hydroxymethyl-4-oxo-pyrrolidine-1-carbonyl)-4,5-dimethoxy-phenyl]-carbamic acid 2,2,2-trichloro-ethyl ester

There total 6 articles about [2-((S)-2-Hydroxymethyl-4-oxo-pyrrolidine-1-carbonyl)-4,5-dimethoxy-phenyl]-carbamic acid 2,2,2-trichloro-ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 689284-02-4
{2-[2-(tert-butyl-dimethyl-silanyloxymethyl)-4-oxo-pyrrolidine-1-carbonyl]-4,5-dimethoxy-phenyl}-carbamic acid 2,2,2-trichloro-ethyl ester

: 689284-03-5
[2-((S)-2-Hydroxymethyl-4-oxo-pyrrolidine-1-carbonyl)-4,5-dimethoxy-phenyl]-carbamic acid 2,2,2-trichloro-ethyl ester

Guidance literature:: With acetic acid; In tetrahydrofuran;
DOI:10.1016/j.bmcl.2003.12.094

Reference yield:

: 4998-07-6
4,5-dimethoxy-2-nitro-benzoic acid

: 689284-03-5
[2-((S)-2-Hydroxymethyl-4-oxo-pyrrolidine-1-carbonyl)-4,5-dimethoxy-phenyl]-carbamic acid 2,2,2-trichloro-ethyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: (COCl)2 / dimethylformamide

2: TEA / CH₂Cl₂

3: 98 percent / hydrazine; Raney nickel / methanol

4: 86 percent / pyridine / CH₂Cl₂

5: 99 percent / (COCl)2; DMSO; TEA / CH₂Cl₂ / -60 °C

6: 93 percent / aq. AcOH / tetrahydrofuran

With pyridine; oxalyl dichloride; TEA; nickel; acetic acid; dimethyl sulfoxide; hydrazine; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide; 5: Swern oxidation;
DOI:10.1016/j.bmcl.2003.12.094

Reference yield:

: 29568-78-3
4,5-dimethoxy-2-nitrobenzoyl chloride

: 689284-03-5
[2-((S)-2-Hydroxymethyl-4-oxo-pyrrolidine-1-carbonyl)-4,5-dimethoxy-phenyl]-carbamic acid 2,2,2-trichloro-ethyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: TEA / CH₂Cl₂

2: 98 percent / hydrazine; Raney nickel / methanol

3: 86 percent / pyridine / CH₂Cl₂

4: 99 percent / (COCl)2; DMSO; TEA / CH₂Cl₂ / -60 °C

5: 93 percent / aq. AcOH / tetrahydrofuran

With pyridine; oxalyl dichloride; TEA; nickel; acetic acid; dimethyl sulfoxide; hydrazine; In tetrahydrofuran; methanol; dichloromethane; 4: Swern oxidation;
DOI:10.1016/j.bmcl.2003.12.094