10-(4-Hydroxy-3-methoxyphenyl)furo[3',4': 6,7]naphtho[1,2-d]-1,3-dioxol-9(7H)-one

Base Information

Chemical Name:10-(4-Hydroxy-3-methoxyphenyl)furo[3',4': 6,7]naphtho[1,2-d]-1,3-dioxol-9(7H)-one
CAS No.:1126088-86-5
Molecular Formula:C₂₀H₁₄O₆
Molecular Weight:350.328
Hs Code.:

Synonyms:10-(4-Hydroxy-3-methoxyphenyl)furo[3',4': 6,7]naphtho[1,2-d]-1,3-dioxol-9(7H)-one

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Chemical Property of 10-(4-Hydroxy-3-methoxyphenyl)furo[3',4': 6,7]naphtho[1,2-d]-1,3-dioxol-9(7H)-one

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Technology Process of 10-(4-Hydroxy-3-methoxyphenyl)furo[3',4': 6,7]naphtho[1,2-d]-1,3-dioxol-9(7H)-one

There total 4 articles about 10-(4-Hydroxy-3-methoxyphenyl)furo[3',4': 6,7]naphtho[1,2-d]-1,3-dioxol-9(7H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 1219694-06-0
10-(4-benzyloxy-3-methoxy-phenyl)-7H-furo[3',4':6,7]naphtho[1,2-d][1,3]dioxol-9-one

: 1126088-86-5
10-(4-Hydroxy-3-methoxyphenyl)furo[3',4': 6,7]naphtho[1,2-d]-1,3-dioxol-9(7H)-one

Guidance literature:: With boron tribromide; In dichloromethane; at -78 ℃; for 2h; Inert atmosphere;
DOI:10.1016/j.bmc.2012.11.037

Reference yield:

: 2426-87-1
3-methoxy-4-(phenylmethoxy)benzaldehyde

: 1126088-86-5
10-(4-Hydroxy-3-methoxyphenyl)furo[3',4': 6,7]naphtho[1,2-d]-1,3-dioxol-9(7H)-one

Guidance literature:: Multi-step reaction with 4 steps

1.1: n-butyllithium / tetrahydrofuran; hexane / 0.33 h / -78 °C / Inert atmosphere

1.2: 3 h / -78 - 20 °C / Inert atmosphere

2.1: acetic anhydride; acetic acid / dichloromethane / 24 h / 140 °C / Inert atmosphere

3.1: sodium tetrahydroborate / tetrahydrofuran / 2 h / 20 °C / Inert atmosphere

4.1: boron tribromide / dichloromethane / 2 h / -78 °C / Inert atmosphere

With sodium tetrahydroborate; n-butyllithium; acetic anhydride; boron tribromide; acetic acid; In tetrahydrofuran; hexane; dichloromethane; 2.1: |Diels-Alder Cycloaddition;
DOI:10.1016/j.bmc.2012.11.037

Reference yield:

: 1219694-11-7
C₂₅H₂₄O₇

: 1126088-86-5
10-(4-Hydroxy-3-methoxyphenyl)furo[3',4': 6,7]naphtho[1,2-d]-1,3-dioxol-9(7H)-one

Guidance literature:: Multi-step reaction with 3 steps

1: acetic anhydride; acetic acid / dichloromethane / 24 h / 140 °C / Inert atmosphere

2: sodium tetrahydroborate / tetrahydrofuran / 2 h / 20 °C / Inert atmosphere

3: boron tribromide / dichloromethane / 2 h / -78 °C / Inert atmosphere

With sodium tetrahydroborate; acetic anhydride; boron tribromide; acetic acid; In tetrahydrofuran; dichloromethane; 1: |Diels-Alder Cycloaddition;
DOI:10.1016/j.bmc.2012.11.037