[6-(4-Chloro-phenyl)-5-oxo-5,6-dihydro-pyrrolo[3,4-b]pyridin-(7E)-ylidene]-acetic acid

Base Information

• Chemical Name: [6-(4-Chloro-phenyl)-5-oxo-5,6-dihydro-pyrrolo[3,4-b]pyridin-(7E)-ylidene]-acetic acid
• CAS No.: 180161-82-4
• Molecular Formula: C₁₅H₉ClN₂O₃
• Molecular Weight: 300.701
• Mol file: 180161-82-4.mol

Synonyms:[6-(4-Chloro-phenyl)-5-oxo-5,6-dihydro-pyrrolo[3,4-b]pyridin-(7E)-ylidene]-acetic acid

Chemical Property of [6-(4-Chloro-phenyl)-5-oxo-5,6-dihydro-pyrrolo[3,4-b]pyridin-(7E)-ylidene]-acetic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of [6-(4-Chloro-phenyl)-5-oxo-5,6-dihydro-pyrrolo[3,4-b]pyridin-(7E)-ylidene]-acetic acid

There total 3 articles about [6-(4-Chloro-phenyl)-5-oxo-5,6-dihydro-pyrrolo[3,4-b]pyridin-(7E)-ylidene]-acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 59.0%

Glyoxilic acid (298-12-4) + 6-(4-Chloro-phenyl)-6,7-dihydro-pyrrolo[3,4-b]pyridin-5-one (180161-81-3) → [6-(4-Chloro-phenyl)-5-oxo-5,6-dihydro-pyrrolo[3,4-b]pyridin-(7E)-ylidene]-acetic acid (180161-82-4)

Guidance literature:

With acetic anhydride; In acetic acid; for 3h; Heating;

DOI:10.1021/jm960325j

Reference yield:

ethyl 2-methyl nicotinate (1721-26-2) → [6-(4-Chloro-phenyl)-5-oxo-5,6-dihydro-pyrrolo[3,4-b]pyridin-(7E)-ylidene]-acetic acid (180161-82-4)

Guidance literature:

Multi-step reaction with 3 steps

1: NBS, (PhCO)2O₂ / CCl₄ / 17 h / Heating

2: ethanol / 72 h / Heating

3: 59 percent / acetic anhydride / acetic acid / 3 h / Heating

With N-Bromosuccinimide; acetic anhydride; dibenzoyl peroxide; In tetrachloromethane; ethanol; acetic acid;

DOI:10.1021/jm960325j

Reference yield:

ethyl 2-bromomethylpyridine-3-carboxylate (63050-11-3) → [6-(4-Chloro-phenyl)-5-oxo-5,6-dihydro-pyrrolo[3,4-b]pyridin-(7E)-ylidene]-acetic acid (180161-82-4)

Guidance literature:

Multi-step reaction with 2 steps

1: ethanol / 72 h / Heating

2: 59 percent / acetic anhydride / acetic acid / 3 h / Heating

With acetic anhydride; In ethanol; acetic acid;

DOI:10.1021/jm960325j

upstream raw materials:

Glyoxilic acid

6-(4-Chloro-phenyl)-6,7-dihydro-pyrrolo[3,4-b]pyridin-5-one

ethyl 2-methyl nicotinate

ethyl 2-bromomethylpyridine-3-carboxylate

Downstream raw materials:

C₂₀H₁₇ClN₂O₅