5-(4-Benzyl-piperazin-1-ylmethyl)-6-thiophen-2-yl-4,5-dihydro-2H-pyridazin-3-one; hydrochloride

Base Information

Chemical Name:5-(4-Benzyl-piperazin-1-ylmethyl)-6-thiophen-2-yl-4,5-dihydro-2H-pyridazin-3-one; hydrochloride
CAS No.:136282-26-3
Molecular Formula:C₂₀H₂₄N₄OS*ClH
Molecular Weight:404.964
Hs Code.:

Synonyms:5-(4-Benzyl-piperazin-1-ylmethyl)-6-thiophen-2-yl-4,5-dihydro-2H-pyridazin-3-one; hydrochloride

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Chemical Property of 5-(4-Benzyl-piperazin-1-ylmethyl)-6-thiophen-2-yl-4,5-dihydro-2H-pyridazin-3-one; hydrochloride

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Technology Process of 5-(4-Benzyl-piperazin-1-ylmethyl)-6-thiophen-2-yl-4,5-dihydro-2H-pyridazin-3-one; hydrochloride

There total 3 articles about 5-(4-Benzyl-piperazin-1-ylmethyl)-6-thiophen-2-yl-4,5-dihydro-2H-pyridazin-3-one; hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

: 135509-64-7
3-(4-Benzyl-piperazin-1-ylmethyl)-4-oxo-4-thiophen-2-yl-butyric acid

: 136282-26-3
5-(4-Benzyl-piperazin-1-ylmethyl)-6-thiophen-2-yl-4,5-dihydro-2H-pyridazin-3-one; hydrochloride

Guidance literature:: With hydrazine hydrate; In ethanol; Heating;
DOI:10.1002/ardp.19913240710

Reference yield:

: 2759-28-6
1-phenylmethylpiperazine

: 136282-26-3
5-(4-Benzyl-piperazin-1-ylmethyl)-6-thiophen-2-yl-4,5-dihydro-2H-pyridazin-3-one; hydrochloride

Guidance literature:: Multi-step reaction with 2 steps

1: 65 percent

2: 69 percent / 98percent hydrazine hydrate / ethanol / Heating

With hydrazine hydrate; In ethanol;
DOI:10.1002/ardp.19913240710

Reference yield:

: 4653-08-1
4-oxo-4-thiophen-2-yl-butyric acid

: 136282-26-3
5-(4-Benzyl-piperazin-1-ylmethyl)-6-thiophen-2-yl-4,5-dihydro-2H-pyridazin-3-one; hydrochloride

Guidance literature:: Multi-step reaction with 2 steps

1: 65 percent

2: 69 percent / 98percent hydrazine hydrate / ethanol / Heating

With hydrazine hydrate; In ethanol;
DOI:10.1002/ardp.19913240710