C₄₁H₅₄O₅Si

Base Information

• Chemical Name: C₄₁H₅₄O₅Si
• CAS No.: 932024-72-1
• Molecular Formula: C₄₁H₅₄O₅Si
• Molecular Weight: 654.962
• Mol file: 932024-72-1.mol

Synonyms:C₄₁H₅₄O₅Si

Chemical Property of C₄₁H₅₄O₅Si

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₄₁H₅₄O₅Si

There total 19 articles about C₄₁H₅₄O₅Si which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

C27H34O2Si (932024-62-9) + C14H19BrO3 (932024-63-0) → C41H54O5Si (932024-72-1)

Guidance literature:

C₁₄H₁₉BrO₃; With tert.-butyl lithium; thien-2-yl(cyano)copper lithium; In tetrahydrofuran; diethyl ether; at -78 - -10 ℃;

C₂₇H₃₄O₂Si; In tetrahydrofuran; diethyl ether; at -78 - -30 ℃; Further stages.;

DOI:10.1016/j.tetlet.2007.01.024

Reference yield:

C11H18O3 (932024-75-4) → C41H54O5Si (932024-72-1)

Guidance literature:

Multi-step reaction with 14 steps

1.1: 97 percent / imidazole; DMAP / dimethylformamide / 60 °C

2.1: O₃ / methanol / -78 °C

2.2: NaBH₄ / methanol / 0 °C

3.1: imidazole; DMAP / CH₂Cl₂; dimethylformamide / 20 °C

4.1: aq. TsOH / acetone / 50 °C

5.1: hydrazine; TEA / ethanol / 100 °C

5.2: 93 percent / I₂; DBU / diethyl ether / 0 - 20 °C

6.1: 100 percent / Cs₂CO₃; Pd(PPh₃)4 / dimethylformamide / 50 °C

7.1: 100 percent / TBAF / tetrahydrofuran / 50 °C

8.1: 100 percent / H₂ / [Ir(COD)Py(PCy₃)]PF₆ / CH₂Cl₂ / 20 °C

9.1: imidazole; DMAP / CH₂Cl₂; dimethylformamide / 20 °C

10.1: Dess-Martin periodinane / CH₂Cl₂ / 20 °C

11.1: TBAF / tetrahydrofuran / 20 °C

12.1: CBr₄; PPh₃ / CH₂Cl₂ / 0 - 20 °C

13.1: 91 percent / TsOH; CH(OEt)3 / CH₂Cl₂ / Heating

14.1: t-BuLi; lithium 2-thienylcyanocuprate / diethyl ether; tetrahydrofuran / -78 - -10 °C

14.2: 91 percent / diethyl ether; tetrahydrofuran / -78 - -30 °C

With 1H-imidazole; dmap; tetrakis(triphenylphosphine) palladium⁽⁰⁾; carbon tetrabromide; TEA; tetrabutyl ammonium fluoride; hydrogen; tert.-butyl lithium; caesium carbonate; Dess-Martin periodane; toluene-4-sulfonic acid; ozone; thien-2-yl(cyano)copper lithium; orthoformic acid triethyl ester; triphenylphosphine; hydrazine; Crabtree's catalyst; In tetrahydrofuran; methanol; diethyl ether; ethanol; dichloromethane; N,N-dimethyl-formamide; acetone; 6.1: Suzuki-Miyaura coupling reaction / 10.1: Dess-Martin oxidation;

DOI:10.1016/j.tetlet.2007.01.024

Reference yield:

C17H32O3Si (932024-67-4) → C41H54O5Si (932024-72-1)

Guidance literature:

Multi-step reaction with 13 steps

1.1: O₃ / methanol / -78 °C

1.2: NaBH₄ / methanol / 0 °C

2.1: imidazole; DMAP / CH₂Cl₂; dimethylformamide / 20 °C

3.1: aq. TsOH / acetone / 50 °C

4.1: hydrazine; TEA / ethanol / 100 °C

4.2: 93 percent / I₂; DBU / diethyl ether / 0 - 20 °C

5.1: 100 percent / Cs₂CO₃; Pd(PPh₃)4 / dimethylformamide / 50 °C

6.1: 100 percent / TBAF / tetrahydrofuran / 50 °C

7.1: 100 percent / H₂ / [Ir(COD)Py(PCy₃)]PF₆ / CH₂Cl₂ / 20 °C

8.1: imidazole; DMAP / CH₂Cl₂; dimethylformamide / 20 °C

9.1: Dess-Martin periodinane / CH₂Cl₂ / 20 °C

10.1: TBAF / tetrahydrofuran / 20 °C

11.1: CBr₄; PPh₃ / CH₂Cl₂ / 0 - 20 °C

12.1: 91 percent / TsOH; CH(OEt)3 / CH₂Cl₂ / Heating

13.1: t-BuLi; lithium 2-thienylcyanocuprate / diethyl ether; tetrahydrofuran / -78 - -10 °C

13.2: 91 percent / diethyl ether; tetrahydrofuran / -78 - -30 °C

With 1H-imidazole; dmap; tetrakis(triphenylphosphine) palladium⁽⁰⁾; carbon tetrabromide; TEA; tetrabutyl ammonium fluoride; hydrogen; tert.-butyl lithium; caesium carbonate; Dess-Martin periodane; toluene-4-sulfonic acid; ozone; thien-2-yl(cyano)copper lithium; orthoformic acid triethyl ester; triphenylphosphine; hydrazine; Crabtree's catalyst; In tetrahydrofuran; methanol; diethyl ether; ethanol; dichloromethane; N,N-dimethyl-formamide; acetone; 5.1: Suzuki-Miyaura coupling reaction / 9.1: Dess-Martin oxidation;

DOI:10.1016/j.tetlet.2007.01.024

upstream raw materials:

C₂₇H₃₄O₂Si

C₁₄H₁₉BrO₃

C₂₇H₃₆OSi

C₁₁H₁₈O₃

Downstream raw materials:

C₃₉H₅₀O₄Si

C₃₉H₅₀O₄Si

C₃₉H₅₂O₃Si

(+)-digitoxigenin

Refernces