ethyl 3-{[(2R,4R)-2-(4,5-diphenyloxazol-2-yl)-4-hydroxypyrrolidin-1-yl]methyl}phenoxyacetate

Base Information

Chemical Name:ethyl 3-{[(2R,4R)-2-(4,5-diphenyloxazol-2-yl)-4-hydroxypyrrolidin-1-yl]methyl}phenoxyacetate
CAS No.:329188-51-4
Molecular Formula:C₃₀H₃₀N₂O₅
Molecular Weight:498.579
Hs Code.:

Synonyms:ethyl 3-{[(2R,4R)-2-(4,5-diphenyloxazol-2-yl)-4-hydroxypyrrolidin-1-yl]methyl}phenoxyacetate

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Chemical Property of ethyl 3-{[(2R,4R)-2-(4,5-diphenyloxazol-2-yl)-4-hydroxypyrrolidin-1-yl]methyl}phenoxyacetate

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Technology Process of ethyl 3-{[(2R,4R)-2-(4,5-diphenyloxazol-2-yl)-4-hydroxypyrrolidin-1-yl]methyl}phenoxyacetate

There total 1 articles about ethyl 3-{[(2R,4R)-2-(4,5-diphenyloxazol-2-yl)-4-hydroxypyrrolidin-1-yl]methyl}phenoxyacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 74232-79-4
3-bromomethyl-1-ethoxycarbonylmethoxybenzene

: (2R,4R)-2-(4,5-diphenyloxazol-2-yl)pyrrolidin-4-ol

: 329188-51-4
ethyl 3-{[(2R,4R)-2-(4,5-diphenyloxazol-2-yl)-4-hydroxypyrrolidin-1-yl]methyl}phenoxyacetate

Guidance literature:: With potassium carbonate; In DMF (N,N-dimethyl-formamide); at 5 - 20 ℃; for 16.5h;

Reference yield:

: 329188-51-4
ethyl 3-{[(2R,4R)-2-(4,5-diphenyloxazol-2-yl)-4-hydroxypyrrolidin-1-yl]methyl}phenoxyacetate

: 329188-55-8
sodium 3-[(2R,4R)-2-(4,5-diphenyloxazol-2-yl)-4-hydroxypyrrolidin-1-ylmethyl]phenoxyacetate

Guidance literature:: With sodium hydroxide; water; In 1,4-dioxane; methanol; at 5 - 20 ℃; for 4h;

Reference yield:

: 329188-51-4
ethyl 3-{[(2R,4R)-2-(4,5-diphenyloxazol-2-yl)-4-hydroxypyrrolidin-1-yl]methyl}phenoxyacetate

: 329188-60-5
ethyl 3-{[(2R)-2-(4,5-diphenyloxazol-2-yl)-4-oxopyrrolidin-1-yl]methyl}phenoxyacetate

Guidance literature:: ethyl 3-{[(2R,4R)-2-(4,5-diphenyloxazol-2-yl)-4-hydroxypyrrolidin-1-yl]methyl}phenoxyacetate; With oxalyl dichloride; dimethyl sulfoxide; In dichloromethane; at -55 ℃; for 1h;

With triethylamine; In dichloromethane; at -55 - 20 ℃; for 1h;