6-Hydroxy-3-[2-[2-(2,4-dichlorophenyl)-5-isopropyl-4-oxazolyl)ethyl]-1,2-benzisoxazole

Base Information

Chemical Name:6-Hydroxy-3-[2-[2-(2,4-dichlorophenyl)-5-isopropyl-4-oxazolyl)ethyl]-1,2-benzisoxazole
CAS No.:515138-13-3
Molecular Formula:C₂₁H₁₈Cl₂N₂O₃
Molecular Weight:417.292
Hs Code.:

Synonyms:6-Hydroxy-3-[2-[2-(2,4-dichlorophenyl)-5-isopropyl-4-oxazolyl)ethyl]-1,2-benzisoxazole

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Chemical Property of 6-Hydroxy-3-[2-[2-(2,4-dichlorophenyl)-5-isopropyl-4-oxazolyl)ethyl]-1,2-benzisoxazole

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Technology Process of 6-Hydroxy-3-[2-[2-(2,4-dichlorophenyl)-5-isopropyl-4-oxazolyl)ethyl]-1,2-benzisoxazole

There total 4 articles about 6-Hydroxy-3-[2-[2-(2,4-dichlorophenyl)-5-isopropyl-4-oxazolyl)ethyl]-1,2-benzisoxazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 17.0%

: 515138-14-4
6-amino-3-[2-[2-(2,4-dichlorophenyl)-5-isopropyl-4-oxazolyl]ethyl]-1,2-benzisoxazole

: 515138-13-3
6-Hydroxy-3-[2-[2-(2,4-dichlorophenyl)-5-isopropyl-4-oxazolyl)ethyl]-1,2-benzisoxazole

Guidance literature:: 6-amino-3-[2-[2-(2,4-dichlorophenyl)-5-isopropyl-4-oxazolyl]ethyl]-1,2-benzisoxazole; With sulfuric acid; sodium nitrite; In water; at 0 ℃; for 0.833333h;

With sulfuric acid; In water; for 4.08333h; Heating / reflux;

Reference yield:

: 1005784-03-1
4-chloromethyl-2-(2,4-dichlorophenyl)-5-isopropyloxazole

: 515138-13-3
6-Hydroxy-3-[2-[2-(2,4-dichlorophenyl)-5-isopropyl-4-oxazolyl)ethyl]-1,2-benzisoxazole

Guidance literature:: Multi-step reaction with 3 steps

1.1: lithium diisopropyl amide / tetrahydrofuran / 0.92 h / -78 °C / Inert atmosphere

1.2: -78 - 20 °C / Inert atmosphere

2.1: hydrogenchloride; water; acetic acid / 24 h / Reflux

2.2: Cooling with ice

3.1: sulfuric acid; water; sodium nitrite / 3.33 h / 0 - 130 °C

With hydrogenchloride; sulfuric acid; water; acetic acid; lithium diisopropyl amide; sodium nitrite; In tetrahydrofuran;
DOI:10.1016/j.bmc.2011.03.053

Reference yield:

: 145508-92-5
6-acetamido-3-methyl-1,2-benzisoxazole

: 515138-13-3
6-Hydroxy-3-[2-[2-(2,4-dichlorophenyl)-5-isopropyl-4-oxazolyl)ethyl]-1,2-benzisoxazole

Guidance literature:: Multi-step reaction with 3 steps

1.1: lithium diisopropyl amide / tetrahydrofuran / 0.92 h / -78 °C / Inert atmosphere

1.2: -78 - 20 °C / Inert atmosphere

2.1: hydrogenchloride; water; acetic acid / 24 h / Reflux

2.2: Cooling with ice

3.1: sulfuric acid; water; sodium nitrite / 3.33 h / 0 - 130 °C

With hydrogenchloride; sulfuric acid; water; acetic acid; lithium diisopropyl amide; sodium nitrite; In tetrahydrofuran;
DOI:10.1016/j.bmc.2011.03.053