Technology Process of 3-(4,4'-dimethoxytrityloxy)methyl-5-fluoromethylbenzylamine
There total 5 articles about 3-(4,4'-dimethoxytrityloxy)methyl-5-fluoromethylbenzylamine which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
triphenylphosphine;
In
tetrahydrofuran; water;
at 20 ℃;
for 15h;
Inert atmosphere;
- Guidance literature:
-
Multi-step reaction with 3 steps
1: sodium tetrahydroborate; methanol / tetrahydrofuran / 20 h / Inert atmosphere; Reflux
2: pyridine / N,N-dimethyl-formamide / 22 h / 20 °C / Inert atmosphere
3: triphenylphosphine / water; tetrahydrofuran / 15 h / 20 °C / Inert atmosphere
With
pyridine; methanol; sodium tetrahydroborate; triphenylphosphine;
In
tetrahydrofuran; water; N,N-dimethyl-formamide;
- Guidance literature:
-
Multi-step reaction with 6 steps
1: diethylamino-sulfur trifluoride / dichloromethane / 2 h / 20 °C / Inert atmosphere
2: sodium tetrahydroborate; methanol / tetrahydrofuran / 1 h / Inert atmosphere; Reflux
3: carbon tetrabromide; triethylamine; sodium azide; triphenylphosphine / N,N-dimethyl-formamide / 93 h / 20 °C / Inert atmosphere
4: sodium tetrahydroborate; methanol / tetrahydrofuran / 20 h / Inert atmosphere; Reflux
5: pyridine / N,N-dimethyl-formamide / 22 h / 20 °C / Inert atmosphere
6: triphenylphosphine / water; tetrahydrofuran / 15 h / 20 °C / Inert atmosphere
With
pyridine; methanol; sodium tetrahydroborate; sodium azide; carbon tetrabromide; diethylamino-sulfur trifluoride; triethylamine; triphenylphosphine;
In
tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide;
