(S)-1-[(1R,3R)-3-(tert-Butyl-dimethyl-silanyloxy)-1-methyl-2-methylene-cyclopentyl]-2-oxo-cyclohexanecarbonitrile

Base Information

Chemical Name:(S)-1-[(1R,3R)-3-(tert-Butyl-dimethyl-silanyloxy)-1-methyl-2-methylene-cyclopentyl]-2-oxo-cyclohexanecarbonitrile
CAS No.:108060-98-6
Molecular Formula:C₂₀H₃₃NO₂Si
Molecular Weight:347.573
Hs Code.:

Synonyms:(S)-1-[(1R,3R)-3-(tert-Butyl-dimethyl-silanyloxy)-1-methyl-2-methylene-cyclopentyl]-2-oxo-cyclohexanecarbonitrile

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Chemical Property of (S)-1-[(1R,3R)-3-(tert-Butyl-dimethyl-silanyloxy)-1-methyl-2-methylene-cyclopentyl]-2-oxo-cyclohexanecarbonitrile

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Technology Process of (S)-1-[(1R,3R)-3-(tert-Butyl-dimethyl-silanyloxy)-1-methyl-2-methylene-cyclopentyl]-2-oxo-cyclohexanecarbonitrile

There total 16 articles about (S)-1-[(1R,3R)-3-(tert-Butyl-dimethyl-silanyloxy)-1-methyl-2-methylene-cyclopentyl]-2-oxo-cyclohexanecarbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 49.0%

: 108060-97-5
2-[5-(tert-Butyl-dimethyl-silanyloxy)-2-methyl-cyclopent-1-enylmethoxy]-cyclohex-1-enecarbonitrile

: 108060-98-6
(S)-1-[(1R,3R)-3-(tert-Butyl-dimethyl-silanyloxy)-1-methyl-2-methylene-cyclopentyl]-2-oxo-cyclohexanecarbonitrile

: 108060-98-6
(R)-1-[(1R,3R)-3-(tert-Butyl-dimethyl-silanyloxy)-1-methyl-2-methylene-cyclopentyl]-2-oxo-cyclohexanecarbonitrile

Guidance literature:: With bis-(trimethylsilyl)acetamide; In various solvent(s); for 6h; Heating;
DOI:10.1021/ja00247a026

Reference yield: 49.0%

: 108060-97-5
2-[5-(tert-Butyl-dimethyl-silanyloxy)-2-methyl-cyclopent-1-enylmethoxy]-cyclohex-1-enecarbonitrile

: 108060-98-6
(S)-1-[(1R,3R)-3-(tert-Butyl-dimethyl-silanyloxy)-1-methyl-2-methylene-cyclopentyl]-2-oxo-cyclohexanecarbonitrile

: 108060-98-6
(R)-1-[(1R,3R)-3-(tert-Butyl-dimethyl-silanyloxy)-1-methyl-2-methylene-cyclopentyl]-2-oxo-cyclohexanecarbonitrile

Guidance literature:: With bis-(trimethylsilyl)acetamide; In various solvent(s); for 6h; Heating;
DOI:10.1021/ja00247a026

Reference yield:

: 4513-77-3
2-cyanocyclohexanone

: 108060-98-6
(S)-1-[(1R,3R)-3-(tert-Butyl-dimethyl-silanyloxy)-1-methyl-2-methylene-cyclopentyl]-2-oxo-cyclohexanecarbonitrile

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) potassium tert-butoxide 2.) NaI / hexamethylphosphoric acid triamide / 25 °C / 1.) 1 h 2.) 4 h

2: 49 percent / bis(trimethylsilyl)acetamide / various solvent(s) / 6 h / Heating

With potassium tert-butylate; bis-(trimethylsilyl)acetamide; sodium iodide; In N,N,N,N,N,N-hexamethylphosphoric triamide;
DOI:10.1021/ja00247a026