Technology Process of 3,4-Pyrrolidinediol, 2-(hydroxymethyl)-5-(2-thienyl)-, (2R,3R,4S,5S)- (9CI)
There total 3 articles about 3,4-Pyrrolidinediol, 2-(hydroxymethyl)-5-(2-thienyl)-, (2R,3R,4S,5S)- (9CI) which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
water; trifluoroacetic acid;
at 50 ℃;
for 2h;
DOI:10.1021/jo960523i
- Guidance literature:
-
Multi-step reaction with 2 steps
1: 34 percent / ammonium formate; NaBH3CN; molecular sieves (3A) / methanol / 18 h / 20 °C
2: 94 percent / trifluoroacetic acid; water / 2 h / 50 °C
With
3 A molecular sieve; water; ammonium formate; sodium cyanoborohydride; trifluoroacetic acid;
In
methanol;
1: Cyclization / 2: Hydrolysis;
DOI:10.1021/jo960523i
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: DMSO; trifluoroacetic anhydride / CH2Cl2 / 2 h / -78 °C
1.2: 80 percent / Et3N / CH2Cl2 / 0.5 h / -78 - 0 °C
2.1: 34 percent / ammonium formate; NaBH3CN; molecular sieves (3A) / methanol / 18 h / 20 °C
3.1: 94 percent / trifluoroacetic acid; water / 2 h / 50 °C
With
3 A molecular sieve; water; ammonium formate; sodium cyanoborohydride; dimethyl sulfoxide; trifluoroacetic acid; trifluoroacetic anhydride;
In
methanol; dichloromethane;
1.1: Swern oxidation / 1.2: Swern oxidation / 2.1: Cyclization / 3.1: Hydrolysis;
DOI:10.1021/jo960523i