3,4-Pyrrolidinediol, 2-(hydroxymethyl)-5-(2-thienyl)-, (2R,3R,4S,5S)- (9CI)

Base Information

Chemical Name:3,4-Pyrrolidinediol, 2-(hydroxymethyl)-5-(2-thienyl)-, (2R,3R,4S,5S)- (9CI)
CAS No.:747398-65-8
Molecular Formula:C₉H₁₃NO₃S
Molecular Weight:215.273
Hs Code.:
Mol file:747398-65-8.mol

Synonyms:3,4-Pyrrolidinediol, 2-(hydroxymethyl)-5-(2-thienyl)-, (2R,3R,4S,5S)- (9CI)

Suppliers and Price of 3,4-Pyrrolidinediol, 2-(hydroxymethyl)-5-(2-thienyl)-, (2R,3R,4S,5S)- (9CI)

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 3,4-Pyrrolidinediol, 2-(hydroxymethyl)-5-(2-thienyl)-, (2R,3R,4S,5S)- (9CI)

Chemical Property:

Boiling Point:433.1±45.0 °C(Predicted)
PKA:13.80±0.70(Predicted)
PSA：100.96000
Density:1.426±0.06 g/cm3(Predicted)
LogP:-0.19610

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

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Technology Process of 3,4-Pyrrolidinediol, 2-(hydroxymethyl)-5-(2-thienyl)-, (2R,3R,4S,5S)- (9CI)

There total 3 articles about 3,4-Pyrrolidinediol, 2-(hydroxymethyl)-5-(2-thienyl)-, (2R,3R,4S,5S)- (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 5-O-(tert-butyldimethylsilyl)-1,4-dideoxy-1,4-imino-2,3-O-isopropylidene-1-(2-thienyl)-β-D-ribitol

: 180895-71-0,747398-65-8
1,4-Dideoxy-1,4-imino-1β-(2'-thienyl)-D-ribitol

Guidance literature:: With water; trifluoroacetic acid; at 50 ℃; for 2h;
DOI:10.1021/jo960523i

Reference yield:

: 180895-65-2
(3S,4R)-1-O-tert-butyldimethylsilyl-1,3,4-trihydroxy-3,4-O-isopropylidene-1-(thiophen-2-yl)-2,5-pentanedione

: 180895-71-0,747398-65-8
1,4-Dideoxy-1,4-imino-1β-(2'-thienyl)-D-ribitol

Guidance literature:: Multi-step reaction with 2 steps

1: 34 percent / ammonium formate; NaBH₃CN; molecular sieves (3A) / methanol / 18 h / 20 °C

2: 94 percent / trifluoroacetic acid; water / 2 h / 50 °C

With 3 A molecular sieve; water; ammonium formate; sodium cyanoborohydride; trifluoroacetic acid; In methanol; 1: Cyclization / 2: Hydrolysis;
DOI:10.1021/jo960523i

Reference yield:

: 196106-54-4
2-(2,3-O-isopropylidene-5-O-tert-butyldimethylsilyl-α,β-D-ribopentitol-1-yl)thiophene

: 180895-71-0,747398-65-8
1,4-Dideoxy-1,4-imino-1β-(2'-thienyl)-D-ribitol

Guidance literature:: Multi-step reaction with 3 steps

1.1: DMSO; trifluoroacetic anhydride / CH₂Cl₂ / 2 h / -78 °C

1.2: 80 percent / Et₃N / CH₂Cl₂ / 0.5 h / -78 - 0 °C

2.1: 34 percent / ammonium formate; NaBH₃CN; molecular sieves (3A) / methanol / 18 h / 20 °C

3.1: 94 percent / trifluoroacetic acid; water / 2 h / 50 °C

With 3 A molecular sieve; water; ammonium formate; sodium cyanoborohydride; dimethyl sulfoxide; trifluoroacetic acid; trifluoroacetic anhydride; In methanol; dichloromethane; 1.1: Swern oxidation / 1.2: Swern oxidation / 2.1: Cyclization / 3.1: Hydrolysis;
DOI:10.1021/jo960523i