N-(2-amino-5-phenylpyridin-3-yl)-7-(piperazin-1-yl)quinoline-3-carboxamide

Base Information

Chemical Name:N-(2-amino-5-phenylpyridin-3-yl)-7-(piperazin-1-yl)quinoline-3-carboxamide
CAS No.:1609389-26-5
Molecular Formula:C₂₅H₂₄N₆O
Molecular Weight:424.505
Hs Code.:

Synonyms:N-(2-amino-5-phenylpyridin-3-yl)-7-(piperazin-1-yl)quinoline-3-carboxamide

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Chemical Property of N-(2-amino-5-phenylpyridin-3-yl)-7-(piperazin-1-yl)quinoline-3-carboxamide

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Technology Process of N-(2-amino-5-phenylpyridin-3-yl)-7-(piperazin-1-yl)quinoline-3-carboxamide

There total 8 articles about N-(2-amino-5-phenylpyridin-3-yl)-7-(piperazin-1-yl)quinoline-3-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 28.0%

: 1609389-84-5
C₂₅H₂₂N₆O₃

: 1609389-26-5
N-(2-amino-5-phenylpyridin-3-yl)-7-(piperazin-1-yl)quinoline-3-carboxamide

Guidance literature:: With ammonium chloride; zinc;

Reference yield:

: 1609389-83-4
C₃₀H₃₀N₆O₅

: 1609389-26-5
N-(2-amino-5-phenylpyridin-3-yl)-7-(piperazin-1-yl)quinoline-3-carboxamide

Guidance literature:: Multi-step reaction with 2 steps

1: trifluoroacetic acid / 4-(dicyanomethylene)-2-methyl-6-(p-dimethylaminostyryl)-4H-pyran

2: zinc; ammonium chloride

With ammonium chloride; trifluoroacetic acid; zinc; In 4-(dicyanomethylene)-2-methyl-6-(p-dimethylaminostyryl)-4H-pyran;

Reference yield:

: 152684-24-7
3-bromo-5-(ethoxycarbonyl)aminopyridine

: 1609389-26-5
N-(2-amino-5-phenylpyridin-3-yl)-7-(piperazin-1-yl)quinoline-3-carboxamide

Guidance literature:: Multi-step reaction with 6 steps

1: sulfuric acid; nitric acid / 0 - 20 °C

2: potassium hydroxide; water / tetrahydrofuran / 90 °C

3: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate

4: trichlorophosphate

5: trifluoroacetic acid / 4-(dicyanomethylene)-2-methyl-6-(p-dimethylaminostyryl)-4H-pyran

6: zinc; ammonium chloride

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sulfuric acid; water; nitric acid; sodium carbonate; ammonium chloride; trifluoroacetic acid; potassium hydroxide; zinc; trichlorophosphate; In tetrahydrofuran; 4-(dicyanomethylene)-2-methyl-6-(p-dimethylaminostyryl)-4H-pyran; 3: |Suzuki Coupling;