4-chloro-6-(4-hydroxyphenyl)-2-thioxo-1,2-dihydropyrimidine-5-carbonitrile

Base Information

• Chemical Name: 4-chloro-6-(4-hydroxyphenyl)-2-thioxo-1,2-dihydropyrimidine-5-carbonitrile
• CAS No.: 1383478-54-3
• Molecular Formula: C₁₁H₆ClN₃OS
• Molecular Weight: 263.707

Synonyms:4-chloro-6-(4-hydroxyphenyl)-2-thioxo-1,2-dihydropyrimidine-5-carbonitrile

Chemical Property of 4-chloro-6-(4-hydroxyphenyl)-2-thioxo-1,2-dihydropyrimidine-5-carbonitrile

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Technology Process of 4-chloro-6-(4-hydroxyphenyl)-2-thioxo-1,2-dihydropyrimidine-5-carbonitrile

There total 2 articles about 4-chloro-6-(4-hydroxyphenyl)-2-thioxo-1,2-dihydropyrimidine-5-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

6-(4-hydroxyphenyl)-4-oxo-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carbonitrile (893759-59-6) → 4-chloro-6-(4-hydroxyphenyl)-2-thioxo-1,2-dihydropyrimidine-5-carbonitrile (1383478-54-3)

Guidance literature:

With phosphorus pentachloride; trichlorophosphate; for 3h; Heating;

DOI:10.1007/s11164-012-0597-7

Reference yield:

4-hydroxy-benzaldehyde (123-08-0,65581-83-1) → 4-chloro-6-(4-hydroxyphenyl)-2-thioxo-1,2-dihydropyrimidine-5-carbonitrile (1383478-54-3)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium ethanolate / 48 h

2: phosphorus pentachloride; trichlorophosphate / 3 h / Heating

With phosphorus pentachloride; sodium ethanolate; trichlorophosphate;

DOI:10.1007/s11164-012-0597-7

Reference yield: 85.0%

4-chloro-6-(4-hydroxyphenyl)-2-thioxo-1,2-dihydropyrimidine-5-carbonitrile (1383478-54-3) → 4-hydrazinyl-6-(4-hydroxyphenyl)-2-thioxo-1,2 dihydropyrimidine-5-carbonitrile (1383478-56-5)

Guidance literature:

With hydrazine hydrate; In methanol; for 8h;

DOI:10.1007/s11164-012-0597-7

upstream raw materials:

6-(4-hydroxyphenyl)-4-oxo-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carbonitrile

4-hydroxy-benzaldehyde

Downstream raw materials:

ethyl{4-cyano-1-[5-cyano-6-(4-hydroxyphenyl)-2-thioxo-1,2-dihydropyrimidin-4-yl]-3-(methylsulfanyl)-1H-pyrazol-5-yl}imidoformate

4-[4-hydrazinyl-3-(methylsulfanyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]-6-(4-hydroxyphenyl)-2-thioxo-1,2-dihydropyrimidine-5-carbonitrile

4-hydrazinyl-6-(4-hydroxyphenyl)-2-thioxo-1,2 dihydropyrimidine-5-carbonitrile

4-[5-amino-4-cyano-3-(methylsulfanyl)-1H-pyrazol-1-yl]-6-(4-hydroxyphenyl)-2-thioxo-1,2-dihydropyrimidine-5-carbonitrile

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