(2SR,3aSR)-2-hydroxymethyl-2-phenyl-2,3,3a,4-tetrahydro-1H-pyrazolo<1.5-a>indole

Base Information

Chemical Name:(2SR,3aSR)-2-hydroxymethyl-2-phenyl-2,3,3a,4-tetrahydro-1H-pyrazolo<1.5-a>indole
CAS No.:130420-55-2
Molecular Formula:C₁₇H₁₈N₂O
Molecular Weight:266.343
Hs Code.:

Synonyms:(2SR,3aSR)-2-hydroxymethyl-2-phenyl-2,3,3a,4-tetrahydro-1H-pyrazolo<1.5-a>indole

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Chemical Property of (2SR,3aSR)-2-hydroxymethyl-2-phenyl-2,3,3a,4-tetrahydro-1H-pyrazolo<1.5-a>indole

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Technology Process of (2SR,3aSR)-2-hydroxymethyl-2-phenyl-2,3,3a,4-tetrahydro-1H-pyrazolo<1.5-a>indole

There total 7 articles about (2SR,3aSR)-2-hydroxymethyl-2-phenyl-2,3,3a,4-tetrahydro-1H-pyrazolo<1.5-a>indole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.9%

: 130420-72-3,130444-10-9
(2SR,3aSR)-2-carbomethoxy-2-phenyl-2,3,3a,4-tetrahydro-1H-pyrazolo<1.5-a>indole

: 130420-55-2
(2SR,3aSR)-2-hydroxymethyl-2-phenyl-2,3,3a,4-tetrahydro-1H-pyrazolo<1.5-a>indole

Guidance literature:: With lithium aluminium tetrahydride; In diethyl ether; for 3h; Ambient temperature;
DOI:10.1248/cpb.38.1129

Reference yield:

: 15206-55-0
methyl 2-oxo-2-phenylacetate

: 130420-55-2
(2SR,3aSR)-2-hydroxymethyl-2-phenyl-2,3,3a,4-tetrahydro-1H-pyrazolo<1.5-a>indole

Guidance literature:: Multi-step reaction with 3 steps

1: 60percent HOAc / 1 h / Ambient temperature

2: 10percent H₂SO₄ / 1,2-dimethoxy-ethane / 1.5 h / Heating

3: 97.9 percent / LiAlH₄ / diethyl ether / 3 h / Ambient temperature

With lithium aluminium tetrahydride; sulfuric acid; acetic acid; In 1,2-dimethoxyethane; diethyl ether;
DOI:10.1248/cpb.38.1129

Reference yield:

: 32704-22-6
2-allyl-phenylamine

: 130420-55-2
(2SR,3aSR)-2-hydroxymethyl-2-phenyl-2,3,3a,4-tetrahydro-1H-pyrazolo<1.5-a>indole

Guidance literature:: Multi-step reaction with 4 steps

1: 1) NaNO₂, 35percent HCl, 2) stannous chloride dihydrate, 35percent HCl / 1) H₂O, below 5 deg C, 2) 0 deg C, 1h

2: 60percent HOAc / 1 h / Ambient temperature

3: 10percent H₂SO₄ / 1,2-dimethoxy-ethane / 1.5 h / Heating

4: 97.9 percent / LiAlH₄ / diethyl ether / 3 h / Ambient temperature

With hydrogenchloride; lithium aluminium tetrahydride; sulfuric acid; acetic acid; tin(ll) chloride; sodium nitrite; In 1,2-dimethoxyethane; diethyl ether;
DOI:10.1248/cpb.38.1129