(4'-(2-(2-(2,6-dichlorophenyl)propan-2-yl)-4-(2-hydroxypropan-2-yl)-1H-imidazol-1-yl)-3,3'-difluoro-5-(methylsulfonyl)biphenyl-4-yl)methyl 3-(phosphonooxymethyl)benzoate

Base Information

Chemical Name:(4'-(2-(2-(2,6-dichlorophenyl)propan-2-yl)-4-(2-hydroxypropan-2-yl)-1H-imidazol-1-yl)-3,3'-difluoro-5-(methylsulfonyl)biphenyl-4-yl)methyl 3-(phosphonooxymethyl)benzoate
CAS No.:1401907-65-0
Molecular Formula:C₃₇H₃₅Cl₂F₂N₂O₉PS
Molecular Weight:823.635
Hs Code.:

(4'-(2-(2-(2,6-dichlorophenyl)propan-2-yl)-4-(2-hydroxypropan-2-yl)-1H-imidazol-1-yl)-3,3'-difluoro-5-(methylsulfonyl)biphenyl-4-yl)methyl 3-(phosphonooxymethyl)benzoate

Synonyms:(4'-(2-(2-(2,6-dichlorophenyl)propan-2-yl)-4-(2-hydroxypropan-2-yl)-1H-imidazol-1-yl)-3,3'-difluoro-5-(methylsulfonyl)biphenyl-4-yl)methyl 3-(phosphonooxymethyl)benzoate

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Chemical Property of (4'-(2-(2-(2,6-dichlorophenyl)propan-2-yl)-4-(2-hydroxypropan-2-yl)-1H-imidazol-1-yl)-3,3'-difluoro-5-(methylsulfonyl)biphenyl-4-yl)methyl 3-(phosphonooxymethyl)benzoate

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Technology Process of (4'-(2-(2-(2,6-dichlorophenyl)propan-2-yl)-4-(2-hydroxypropan-2-yl)-1H-imidazol-1-yl)-3,3'-difluoro-5-(methylsulfonyl)biphenyl-4-yl)methyl 3-(phosphonooxymethyl)benzoate

There total 3 articles about (4'-(2-(2-(2,6-dichlorophenyl)propan-2-yl)-4-(2-hydroxypropan-2-yl)-1H-imidazol-1-yl)-3,3'-difluoro-5-(methylsulfonyl)biphenyl-4-yl)methyl 3-(phosphonooxymethyl)benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 38.0%

: 1401907-84-3
C₄₅H₅₁Cl₂F₂N₂O₉PS

: 1401907-65-0
(4'-(2-(2-(2,6-dichlorophenyl)propan-2-yl)-4-(2-hydroxypropan-2-yl)-1H-imidazol-1-yl)-3,3'-difluoro-5-(methylsulfonyl)biphenyl-4-yl)methyl 3-(phosphonooxymethyl)benzoate

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 0 - 20 ℃; for 4.16667h;

Reference yield:

: 1129-28-8
3-methoxycarbonylbenzyl bromide

: 1401907-65-0
(4'-(2-(2-(2,6-dichlorophenyl)propan-2-yl)-4-(2-hydroxypropan-2-yl)-1H-imidazol-1-yl)-3,3'-difluoro-5-(methylsulfonyl)biphenyl-4-yl)methyl 3-(phosphonooxymethyl)benzoate

Guidance literature:: Multi-step reaction with 4 steps

1: tetrahydrofuran / 2 h / 70 °C

2: water; lithium hydroxide / tetrahydrofuran; methanol / 1 h / 20 °C

3: dmap; dicyclohexyl-carbodiimide / dichloromethane / 15 h / 20 °C

4: trifluoroacetic acid / dichloromethane / 4.17 h / 0 - 20 °C

With dmap; water; dicyclohexyl-carbodiimide; trifluoroacetic acid; lithium hydroxide; In tetrahydrofuran; methanol; dichloromethane;

Reference yield:

: 1401907-80-9
methyl 3-(((di-tert-butoxyphosphoryl)oxy)methyl)benzoate

: 1401907-65-0
(4'-(2-(2-(2,6-dichlorophenyl)propan-2-yl)-4-(2-hydroxypropan-2-yl)-1H-imidazol-1-yl)-3,3'-difluoro-5-(methylsulfonyl)biphenyl-4-yl)methyl 3-(phosphonooxymethyl)benzoate

Guidance literature:: Multi-step reaction with 3 steps

1: water; lithium hydroxide / tetrahydrofuran; methanol / 1 h / 20 °C

2: dmap; dicyclohexyl-carbodiimide / dichloromethane / 15 h / 20 °C

3: trifluoroacetic acid / dichloromethane / 4.17 h / 0 - 20 °C

With dmap; water; dicyclohexyl-carbodiimide; trifluoroacetic acid; lithium hydroxide; In tetrahydrofuran; methanol; dichloromethane;