(+/-)-5-(3-trifluoromethyl-phenyl)-1-(4-trifluoromethoxy-phenyl)-3-(4-trifluoromethoxy-phenylamino)-1,5-dihydro-pyrrol-2-one

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Chemical Name:(+/-)-5-(3-trifluoromethyl-phenyl)-1-(4-trifluoromethoxy-phenyl)-3-(4-trifluoromethoxy-phenylamino)-1,5-dihydro-pyrrol-2-one
CAS No.:1032524-72-3
Molecular Formula:C₂₅H₁₅F₉N₂O₃
Molecular Weight:562.391
Hs Code.:

Synonyms:(+/-)-5-(3-trifluoromethyl-phenyl)-1-(4-trifluoromethoxy-phenyl)-3-(4-trifluoromethoxy-phenylamino)-1,5-dihydro-pyrrol-2-one

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Chemical Property of (+/-)-5-(3-trifluoromethyl-phenyl)-1-(4-trifluoromethoxy-phenyl)-3-(4-trifluoromethoxy-phenylamino)-1,5-dihydro-pyrrol-2-one

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Technology Process of (+/-)-5-(3-trifluoromethyl-phenyl)-1-(4-trifluoromethoxy-phenyl)-3-(4-trifluoromethoxy-phenylamino)-1,5-dihydro-pyrrol-2-one

There total 1 articles about (+/-)-5-(3-trifluoromethyl-phenyl)-1-(4-trifluoromethoxy-phenyl)-3-(4-trifluoromethoxy-phenylamino)-1,5-dihydro-pyrrol-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 617-35-6
2-oxo-propionic acid ethyl ester

: 461-82-5
4-(trifluoromethoxy)aniline

: 454-89-7
3-Trifluoromethylbenzaldehyde

: 1032524-72-3
(+/-)-5-(3-trifluoromethyl-phenyl)-1-(4-trifluoromethoxy-phenyl)-3-(4-trifluoromethoxy-phenylamino)-1,5-dihydro-pyrrol-2-one

Guidance literature:: In acetic acid; at 20 ℃; for 6h;

Reference yield:

: 1032524-72-3
(+/-)-5-(3-trifluoromethyl-phenyl)-1-(4-trifluoromethoxy-phenyl)-3-(4-trifluoromethoxy-phenylamino)-1,5-dihydro-pyrrol-2-one

: 1032526-56-9
(+/-)-1-(4-trifluoromethoxy-phenyl)-5-(3-trifluoromethyl-phenyl)-pyrrolidine-2,3-dione

Guidance literature:: (+/-)-5-(3-trifluoromethyl-phenyl)-1-(4-trifluoromethoxy-phenyl)-3-(4-trifluoromethoxy-phenylamino)-1,5-dihydro-pyrrol-2-one; With cis,trans-2,5-dimethoxytetrahydrofuran; acetic acid; trifluoroacetic acid; In tetrahydrofuran; water; at 35 ℃; for 72h;

With sodium hydrogencarbonate; In Isopropyl acetate; toluene;

Reference yield:

: 1032524-72-3
(+/-)-5-(3-trifluoromethyl-phenyl)-1-(4-trifluoromethoxy-phenyl)-3-(4-trifluoromethoxy-phenylamino)-1,5-dihydro-pyrrol-2-one

: (+/-)-3-[1-methyl-1-(6-trifluoromethyl-pyridin-2-yl)-ethylamino]-1-(4-trifluoromethoxy-phenyl)-5-(3-trifluoromethyl-phenyl)-pyrrolidin-2-one

Guidance literature:: Multi-step reaction with 3 steps

1: cis,trans-2,5-dimethoxytetrahydrofuran; acetic acid; trifluoroacetic acid / tetrahydrofuran; water / 72 h / 35 °C

2: acetic acid / toluene / 1.5 h / 55 °C

3: sodium cyanoborohydride; acetic acid / 0.5 h / 20 °C

With cis,trans-2,5-dimethoxytetrahydrofuran; sodium cyanoborohydride; acetic acid; trifluoroacetic acid; In tetrahydrofuran; water; toluene;