(4R,8aS)-2-(2-phenylethyl)-4-phenyl-perhydropyrrole[1,2-a]pyrazine-1,3-dione

Base Information

Chemical Name:(4R,8aS)-2-(2-phenylethyl)-4-phenyl-perhydropyrrole[1,2-a]pyrazine-1,3-dione
CAS No.:1341215-04-0
Molecular Formula:C₂₁H₂₂N₂O₂
Molecular Weight:334.418
Hs Code.:

Synonyms:(4R,8aS)-2-(2-phenylethyl)-4-phenyl-perhydropyrrole[1,2-a]pyrazine-1,3-dione

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Chemical Property of (4R,8aS)-2-(2-phenylethyl)-4-phenyl-perhydropyrrole[1,2-a]pyrazine-1,3-dione

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Technology Process of (4R,8aS)-2-(2-phenylethyl)-4-phenyl-perhydropyrrole[1,2-a]pyrazine-1,3-dione

There total 5 articles about (4R,8aS)-2-(2-phenylethyl)-4-phenyl-perhydropyrrole[1,2-a]pyrazine-1,3-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: (4R,8aS)-4-phenyl-perhydropyrrolo[1,2-a]pyrazine-1,3-dione

: 103-63-9
1-phenyl-2-bromoethane

: 1341215-04-0
(4R,8aS)-2-(2-phenylethyl)-4-phenyl-perhydropyrrole[1,2-a]pyrazine-1,3-dione

Guidance literature:: With tetrabutylammomium bromide; potassium carbonate; In acetone; for 1h; Reflux;
DOI:10.1016/j.ejmech.2011.07.027

Reference yield:

: 147-85-3,25191-13-3,37159-97-0,4305-67-3,4607-28-7
L-proline

: 1341215-04-0
(4R,8aS)-2-(2-phenylethyl)-4-phenyl-perhydropyrrole[1,2-a]pyrazine-1,3-dione

Guidance literature:: Multi-step reaction with 5 steps

1.1: thionyl chloride / methanol / 2 h / Reflux

1.2: 20 °C

2.1: ammonia / methanol / 72 h / 20 °C

3.1: pyridine / acetonitrile / 2 h / Reflux

4.1: sodium hydroxide / ethanol / 0.17 h / 20 °C

5.1: tetrabutylammomium bromide; potassium carbonate / acetone / 1 h / Reflux

With pyridine; thionyl chloride; tetrabutylammomium bromide; ammonia; potassium carbonate; sodium hydroxide; In methanol; ethanol; acetone; acetonitrile;
DOI:10.1016/j.ejmech.2011.07.027

Reference yield:

: 958852-31-8
(2S,αR)-α-(2-carbamoylpyrrolidin-1-yl)-α-phenylacetic acid methyl ester

: 1341215-04-0
(4R,8aS)-2-(2-phenylethyl)-4-phenyl-perhydropyrrole[1,2-a]pyrazine-1,3-dione

Guidance literature:: Multi-step reaction with 2 steps

1: sodium hydroxide / ethanol / 0.17 h / 20 °C

2: tetrabutylammomium bromide; potassium carbonate / acetone / 1 h / Reflux

With tetrabutylammomium bromide; potassium carbonate; sodium hydroxide; In ethanol; acetone;
DOI:10.1016/j.ejmech.2011.07.027