Technology Process of (S)-1-(4-(2-(3-aminophenyl)-1H-imidazol-1-yl)pyrimidin-2-ylamino)propan-2-ol
There total 5 articles about (S)-1-(4-(2-(3-aminophenyl)-1H-imidazol-1-yl)pyrimidin-2-ylamino)propan-2-ol which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
hydrogen;
palladium 10% on activated carbon;
In
methanol;
at 20 ℃;
for 6h;
- Guidance literature:
-
Multi-step reaction with 2 steps
1: tetrahydrofuran / 8 h / 60 °C
2: hydrogen / palladium 10% on activated carbon / methanol / 6 h / 20 °C
With
hydrogen;
palladium 10% on activated carbon;
In
tetrahydrofuran; methanol;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: sodium methylate / methanol / 5 h
1.2: 1 h / 70 °C
1.3: 3 h / 70 °C
2.1: potassium phosphate / palladium diacetate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl / toluene / 3 h / 130 °C
3.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 8 h / 20 °C
4.1: tetrahydrofuran / 8 h / 60 °C
5.1: hydrogen / palladium 10% on activated carbon / methanol / 6 h / 20 °C
With
potassium phosphate; hydrogen; sodium methylate; 3-chloro-benzenecarboperoxoic acid;
palladium 10% on activated carbon; palladium diacetate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl;
In
tetrahydrofuran; methanol; dichloromethane; toluene;
