(S)-1-(4-(2-(3-aminophenyl)-1H-imidazol-1-yl)pyrimidin-2-ylamino)propan-2-ol

Base Information

Chemical Name:(S)-1-(4-(2-(3-aminophenyl)-1H-imidazol-1-yl)pyrimidin-2-ylamino)propan-2-ol
CAS No.:1220701-20-1
Molecular Formula:C₁₆H₁₈N₆O
Molecular Weight:310.359
Hs Code.:

Synonyms:(S)-1-(4-(2-(3-aminophenyl)-1H-imidazol-1-yl)pyrimidin-2-ylamino)propan-2-ol

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Chemical Property of (S)-1-(4-(2-(3-aminophenyl)-1H-imidazol-1-yl)pyrimidin-2-ylamino)propan-2-ol

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Technology Process of (S)-1-(4-(2-(3-aminophenyl)-1H-imidazol-1-yl)pyrimidin-2-ylamino)propan-2-ol

There total 5 articles about (S)-1-(4-(2-(3-aminophenyl)-1H-imidazol-1-yl)pyrimidin-2-ylamino)propan-2-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

: 1220701-18-7
(S)-1-(4-(2-(3-nitrophenyl)-1H-imidazol-1-yl)pyrimidin2-ylamino)propan-2-ol

: 1220701-20-1
(S)-1-(4-(2-(3-aminophenyl)-1H-imidazol-1-yl)pyrimidin-2-ylamino)propan-2-ol

Guidance literature:: With hydrogen; palladium 10% on activated carbon; In methanol; at 20 ℃; for 6h;

Reference yield:

: 1220701-16-5
2-(methylsulfonyl)-4-(2-(3-nitrophenyl)-1H-imidazol-1-yl)pyrimidine

: 1220701-20-1
(S)-1-(4-(2-(3-aminophenyl)-1H-imidazol-1-yl)pyrimidin-2-ylamino)propan-2-ol

Guidance literature:: Multi-step reaction with 2 steps

1: tetrahydrofuran / 8 h / 60 °C

2: hydrogen / palladium 10% on activated carbon / methanol / 6 h / 20 °C

With hydrogen; palladium 10% on activated carbon; In tetrahydrofuran; methanol;

Reference yield:

: 619-24-9
3-nitrobenzonitrile

: 1220701-20-1
(S)-1-(4-(2-(3-aminophenyl)-1H-imidazol-1-yl)pyrimidin-2-ylamino)propan-2-ol

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium methylate / methanol / 5 h

1.2: 1 h / 70 °C

1.3: 3 h / 70 °C

2.1: potassium phosphate / palladium diacetate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl / toluene / 3 h / 130 °C

3.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 8 h / 20 °C

4.1: tetrahydrofuran / 8 h / 60 °C

5.1: hydrogen / palladium 10% on activated carbon / methanol / 6 h / 20 °C

With potassium phosphate; hydrogen; sodium methylate; 3-chloro-benzenecarboperoxoic acid; palladium 10% on activated carbon; palladium diacetate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; In tetrahydrofuran; methanol; dichloromethane; toluene;