-4-<<(Methoxycarbonyl)phenylmethyl>amino>-4-oxo-2-butenoic acid

Base Information

• Chemical Name: -4-<<(Methoxycarbonyl)phenylmethyl>amino>-4-oxo-2-butenoic acid
• CAS No.: 120566-65-6
• Molecular Formula: C₁₃H₁₃NO₅
• Molecular Weight: 263.25
• Mol file: 120566-65-6.mol

Synonyms:-4-<<(Methoxycarbonyl)phenylmethyl>amino>-4-oxo-2-butenoic acid

Chemical Property of -4-<<(Methoxycarbonyl)phenylmethyl>amino>-4-oxo-2-butenoic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of -4-<<(Methoxycarbonyl)phenylmethyl>amino>-4-oxo-2-butenoic acid

There total 1 articles about -4-<<(Methoxycarbonyl)phenylmethyl>amino>-4-oxo-2-butenoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

maleic anhydride (108-31-6) + (S)-Phenylglycine methyl ester (6591-61-3,24461-61-8,26682-99-5,37760-98-8) → -4-<<(Methoxycarbonyl)phenylmethyl>amino>-4-oxo-2-butenoic acid (120566-65-6)

Guidance literature:

In diethyl ether; for 20h; Ambient temperature;

DOI:10.1021/jo00020a035

Reference yield:

-4-<<(Methoxycarbonyl)phenylmethyl>amino>-4-oxo-2-butenoic acid (120566-65-6) → (S)-(-)-N-<α-(methoxycarbonyl)benzyl>maleimide (120566-67-8)

Guidance literature:

With 1,1,1,3,3,3-hexamethyl-disilazane; zinc dibromide; In benzene; for 2h; Yield given; Heating;

DOI:10.1021/jo962202c

Reference yield:

-4-<<(Methoxycarbonyl)phenylmethyl>amino>-4-oxo-2-butenoic acid (120566-65-6) → <3aS<1<1S*,3(R*,S*),5R*,6R*>,3aα,6α,7aβ>>-8-Methyl-2,4-dioxo-α-phenyl-6-<(tetrahydro-8,8-dimethyl-3H-3a,6-methano-2,1-benzisothiazol-1(4H)-yl)carbonyl>-3,8-diazabicyclo<3.2.1>octane 3-acetic acid methyl ester S,S-dioxide (127381-62-8,127420-42-2)

Guidance literature:

Multi-step reaction with 4 steps

1: 1.) 1-ethyl-3-<3-(dimethylamino)propyl>carbodiimide hydrochloride / 1.) CH₂Cl₂ or THF, r.t., 20 h, 2.) toluene, 100 deg C, 18 h

2: 91 percent / toluene / 24 h / Ambient temperature

3: 82 percent / dioxane / 5 h / Irradiation

4: 61 percent / dioxane / Irradiation; repeated portionwise addition of dipolarophile

With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In 1,4-dioxane; toluene;

DOI:10.1021/jo00020a035

upstream raw materials:

maleic anhydride

(S)-Phenylglycine methyl ester

Downstream raw materials:

(S)-(-)-N-<α-(methoxycarbonyl)benzyl>maleimide

(+/-)-α-Phenyl-2,5-dioxo-1H-pyrrole-1-acetic acid methyl ester

(+/-)-α-Phenyl-2,5-dioxo-3-<(benzotriazol-1-yl)oxy>pyrrolidine-1-acetic acid methyl ester

(S)-(6-Methyl-2,4-dioxo-3,6-diaza-bicyclo[3.1.0]hex-3-yl)-phenyl-acetic acid methyl ester