Acetic acid (E)-(S)-4-(tert-butyl-diphenyl-silanyloxy)-1-(2,2-dimethyl-3-phenylsulfanyl-propionyl)-2-[2-(4-methoxy-benzyloxy)-ethyl]-but-2-enyl ester

Base Information

Chemical Name:Acetic acid (E)-(S)-4-(tert-butyl-diphenyl-silanyloxy)-1-(2,2-dimethyl-3-phenylsulfanyl-propionyl)-2-[2-(4-methoxy-benzyloxy)-ethyl]-but-2-enyl ester
CAS No.:218435-09-7
Molecular Formula:C₄₃H₅₂O₆SSi
Molecular Weight:725.034
Hs Code.:

Synonyms:Acetic acid (E)-(S)-4-(tert-butyl-diphenyl-silanyloxy)-1-(2,2-dimethyl-3-phenylsulfanyl-propionyl)-2-[2-(4-methoxy-benzyloxy)-ethyl]-but-2-enyl ester

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Chemical Property of Acetic acid (E)-(S)-4-(tert-butyl-diphenyl-silanyloxy)-1-(2,2-dimethyl-3-phenylsulfanyl-propionyl)-2-[2-(4-methoxy-benzyloxy)-ethyl]-but-2-enyl ester

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Technology Process of Acetic acid (E)-(S)-4-(tert-butyl-diphenyl-silanyloxy)-1-(2,2-dimethyl-3-phenylsulfanyl-propionyl)-2-[2-(4-methoxy-benzyloxy)-ethyl]-but-2-enyl ester

There total 8 articles about Acetic acid (E)-(S)-4-(tert-butyl-diphenyl-silanyloxy)-1-(2,2-dimethyl-3-phenylsulfanyl-propionyl)-2-[2-(4-methoxy-benzyloxy)-ethyl]-but-2-enyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 218435-08-6
Acetic acid (E)-(S)-4-(tert-butyl-diphenyl-silanyloxy)-1-((R)-1-hydroxy-2,2-dimethyl-3-phenylsulfanyl-propyl)-2-[2-(4-methoxy-benzyloxy)-ethyl]-but-2-enyl ester

: 218435-09-7
Acetic acid (E)-(S)-4-(tert-butyl-diphenyl-silanyloxy)-1-(2,2-dimethyl-3-phenylsulfanyl-propionyl)-2-[2-(4-methoxy-benzyloxy)-ethyl]-but-2-enyl ester

Guidance literature:: With dipyridinium dichromate; 4 Angstroems MS; In dichloromethane; for 24h; Ambient temperature;
DOI:10.1016/S0040-4020(98)00889-8

Reference yield:

: 133094-78-7
3-(tert-butyldimethylsilanyloxy)-4,4-dimethyldihydro-2(3H)-furan-2-one

: 218435-09-7
Acetic acid (E)-(S)-4-(tert-butyl-diphenyl-silanyloxy)-1-(2,2-dimethyl-3-phenylsulfanyl-propionyl)-2-[2-(4-methoxy-benzyloxy)-ethyl]-but-2-enyl ester

Guidance literature:: Multi-step reaction with 9 steps

1: 98 percent / Me₃Al / hexane; benzene / 1 h / Ambient temperature

2: CBr₄, PPh₃ / acetonitrile / 2 h / Ambient temperature

3: DBU / benzene / 48 h / Heating

4: 65 percent / di-isobutylaluminium hydride / hexane; CH₂Cl₂ / 2 h / -78 °C

5: 1.) n-BuLi / 1.) THF, hexane, -78 deg C, 30 min, 2.) THF, hexane, -78 deg C, 45 min

6: 97 percent / TBAF / tetrahydrofuran / 3 h / Ambient temperature

7: 89 percent / DMAP, Et₃N / 16 h / Ambient temperature

8: 50 percent / DMAP / CH₂Cl₂; pyridine / 24 h / Heating

9: 76 percent / PDC, 4 Angstroems MS / CH₂Cl₂ / 24 h / Ambient temperature

With dmap; dipyridinium dichromate; n-butyllithium; diisobutylaluminum hydride; carbon tetrabromide; 4 Angstroems MS; tetrabutyl ammonium fluoride; trimethylaluminum; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; triphenylphosphine; In tetrahydrofuran; pyridine; hexane; dichloromethane; acetonitrile; benzene;
DOI:10.1016/S0040-4020(98)00889-8

Reference yield:

: 58479-61-1
tert-butylchlorodiphenylsilane

: 218435-09-7
Acetic acid (E)-(S)-4-(tert-butyl-diphenyl-silanyloxy)-1-(2,2-dimethyl-3-phenylsulfanyl-propionyl)-2-[2-(4-methoxy-benzyloxy)-ethyl]-but-2-enyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 89 percent / DMAP, Et₃N / 16 h / Ambient temperature

2: 50 percent / DMAP / CH₂Cl₂; pyridine / 24 h / Heating

3: 76 percent / PDC, 4 Angstroems MS / CH₂Cl₂ / 24 h / Ambient temperature

With dmap; dipyridinium dichromate; 4 Angstroems MS; triethylamine; In pyridine; dichloromethane;
DOI:10.1016/S0040-4020(98)00889-8