2-chloro-4-[4-(2-chlorophenyl)-3-(1H-1,2,4-triazol-3-yl)-1H-pyrazol-1-yl]pyridine

Base Information

Chemical Name:2-chloro-4-[4-(2-chlorophenyl)-3-(1H-1,2,4-triazol-3-yl)-1H-pyrazol-1-yl]pyridine
CAS No.:1445891-23-5
Molecular Formula:C₁₆H₁₀Cl₂N₆
Molecular Weight:357.202
Hs Code.:

Synonyms:2-chloro-4-[4-(2-chlorophenyl)-3-(1H-1,2,4-triazol-3-yl)-1H-pyrazol-1-yl]pyridine

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Chemical Property of 2-chloro-4-[4-(2-chlorophenyl)-3-(1H-1,2,4-triazol-3-yl)-1H-pyrazol-1-yl]pyridine

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Technology Process of 2-chloro-4-[4-(2-chlorophenyl)-3-(1H-1,2,4-triazol-3-yl)-1H-pyrazol-1-yl]pyridine

There total 5 articles about 2-chloro-4-[4-(2-chlorophenyl)-3-(1H-1,2,4-triazol-3-yl)-1H-pyrazol-1-yl]pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 20.0%

: 1445891-21-3
4-(2-chlorophenyl)-1-(2-chloropyridin-4-yl)-1H-pyrazole-3-carboxamide

: 4637-24-5
N,N-dimethyl-formamide dimethyl acetal

: 1445891-23-5
2-chloro-4-[4-(2-chlorophenyl)-3-(1H-1,2,4-triazol-3-yl)-1H-pyrazol-1-yl]pyridine

Guidance literature:: 4-(2-chlorophenyl)-1-(2-chloropyridin-4-yl)-1H-pyrazole-3-carboxamide; N,N-dimethyl-formamide dimethyl acetal; With hydrazine hydrate; In toluene; at 20 - 50 ℃; for 2h;

With hydrazine hydrate; In acetic acid; toluene; at 20 ℃; for 1h;

Reference yield:

: 1445891-15-5
methyl 4-(2-chlorophenyl)-1-(2-chloropyridin-4-yl)-1H-pyrazole-3-carboxylate

: 1445891-23-5
2-chloro-4-[4-(2-chlorophenyl)-3-(1H-1,2,4-triazol-3-yl)-1H-pyrazol-1-yl]pyridine

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydroxide / tetrahydrofuran; water / 20 °C

2.1: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; ammonia; N-ethyl-N,N-diisopropylamine / dichloromethane; 1,4-dioxane

3.1: hydrazine hydrate / toluene / 2 h / 20 - 50 °C

3.2: 1 h / 20 °C

With ammonia; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; hydrazine hydrate; N-ethyl-N,N-diisopropylamine; sodium hydroxide; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water; toluene;

Reference yield:

: 3900-89-8
2-Chlorobenzeneboronic acid

: 1445891-23-5
2-chloro-4-[4-(2-chlorophenyl)-3-(1H-1,2,4-triazol-3-yl)-1H-pyrazol-1-yl]pyridine

Guidance literature:: Multi-step reaction with 5 steps

1.1: caesium carbonate; tetrakis(triphenylphosphine)palladium ⁽⁰⁾ / 1,4-dioxane; water / 0.67 h / 150 °C / Sealed tube; Microwave irradiation

2.1: trans-N,N'-dimethyl-1,2-cyclohexyldiamine; copper(l) iodide / 1,4-dioxane / 1 h / 100 °C

3.1: sodium hydroxide / tetrahydrofuran; water / 20 °C

4.1: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; ammonia; N-ethyl-N,N-diisopropylamine / dichloromethane; 1,4-dioxane

5.1: hydrazine hydrate / toluene / 2 h / 20 - 50 °C

5.2: 1 h / 20 °C

With trans-N,N'-dimethyl-1,2-cyclohexyldiamine; copper(l) iodide; ammonia; caesium carbonate; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; hydrazine hydrate; N-ethyl-N,N-diisopropylamine; tetrakis(triphenylphosphine)palladium ⁽⁰⁾; sodium hydroxide; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water; toluene;