1,3-dibenzyl-6-hydroxy-tetrahydro-furo[3,4-d]imidazole-2,4-dione

Base Information

• Chemical Name: 1,3-dibenzyl-6-hydroxy-tetrahydro-furo[3,4-d]imidazole-2,4-dione
• CAS No.: 21035-81-4
• Molecular Formula: C₁₉H₁₈N₂O₄
• Molecular Weight: 338.363
• Mol file: 21035-81-4.mol

Synonyms:1,3-dibenzyl-6-hydroxy-tetrahydro-furo[3,4-d]imidazole-2,4-dione

Chemical Property of 1,3-dibenzyl-6-hydroxy-tetrahydro-furo[3,4-d]imidazole-2,4-dione

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1,3-dibenzyl-6-hydroxy-tetrahydro-furo[3,4-d]imidazole-2,4-dione

There total 12 articles about 1,3-dibenzyl-6-hydroxy-tetrahydro-furo[3,4-d]imidazole-2,4-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

Acetic acid (3aR,4R,6aS)-1,3-dibenzyl-2,6-dioxo-hexahydro-furo[3,4-d]imidazol-4-yl ester (28092-55-9) → (3aRS,6SR,6aSR)-1,3-dibenzyl-6-hydroxy-3,3a,6,6a-tetrahydro-1H-furo<3,4-d>imidazole-2,4-dione (21035-81-4,55529-05-0,55529-06-1,129388-89-2,129388-92-7)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; for 2.5h; Ambient temperature;

DOI:10.1248/cpb.38.882

Reference yield: 42.0%

(4S,5R)-1,3-Dibenzyl-5-[(2S,5S)-3-(3-dimethylamino-propyl)-5-((1S,2R,3R)-1,2,3,4-tetrahydroxy-butyl)-oxazolidin-2-yl]-2-oxo-imidazolidine-4-carboxylic acid (129301-70-8) → (3aS,6R,6aR)-1,3-dibenzyl-6-hydroxy-3,3a,6,6a-tetrahydro-1H-furo<3,4-d>imidazole-2,4-dione (21035-81-4,55529-05-0,55529-06-1,129388-89-2,129388-92-7)

Guidance literature:

With hydrogenchloride;

DOI:10.1248/cpb.38.882

Reference yield: 41.0%

(4S,5R)-1,3-dibenzyl-1H-furo[3,4-d]imidazole-2,4,6-trione (26339-42-4,26340-00-1) → (3aS)-1,3-dibenzyl-6ξ-hydroxy-(3ar,6ac)-tetrahydro-furo[3,4-d]imidazole-2,4-dione (21035-81-4,55529-05-0,55529-06-1,129388-89-2,129388-92-7)

Guidance literature:

With lithium aluminium tetrahydride; ethanol; (R)-1,1'-Bi-2-naphthol; In tetrahydrofuran; at -78 ℃; for 5h;

DOI:10.1248/cpb.42.9

upstream raw materials:

(4S,5R)-1,3-dibenzyl-1H-furo[3,4-d]imidazole-2,4,6-trione

(4S,5R)-1,3-dibenzyl-5-formyl-2-oxo-4-imidazolidine carboxylic acid cinchonidine salt

(4S,5R)-1,3-Dibenzyl-5-[(2S,5S)-3-(3-dimethylamino-propyl)-5-((1S,2R,3R)-1,2,3,4-tetrahydroxy-butyl)-oxazolidin-2-yl]-2-oxo-imidazolidine-4-carboxylic acid

Acetic acid (3aR,4R,6aS)-1,3-dibenzyl-2,6-dioxo-hexahydro-furo[3,4-d]imidazol-4-yl ester

Downstream raw materials:

(3aS,6aR)-1,3-dibenzyltetrahydro-1H-furo[3,4-d]imidazole-2,4-dione

(4S,5R)-1,3-dibenzyl-5-hydroxymethyl-2-oxoimidazolidine-4-carboxylic acid lactone

(4S,5R)-1,3-dibenzyl-5-formyl-2-oxo-4-imidazolidine carboxylic acid cinchonidine salt

(3aR,6S,6aS)-1,3-dibenzyl-6-hydroxy-3,3a,6,6a-tetrahydro-1H-furo<3,4-d>imidazole-2,4-dione