2-(4-fluorophenyl)-2-(4,6-dimethyl-2-hydroxyphenyl)-N-(4-methylphenylsulfonyl)-ethanamine

Base Information

Chemical Name:2-(4-fluorophenyl)-2-(4,6-dimethyl-2-hydroxyphenyl)-N-(4-methylphenylsulfonyl)-ethanamine
CAS No.:897960-96-2
Molecular Formula:C₂₃H₂₄FNO₃S
Molecular Weight:413.513
Hs Code.:

Synonyms:2-(4-fluorophenyl)-2-(4,6-dimethyl-2-hydroxyphenyl)-N-(4-methylphenylsulfonyl)-ethanamine

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Chemical Property of 2-(4-fluorophenyl)-2-(4,6-dimethyl-2-hydroxyphenyl)-N-(4-methylphenylsulfonyl)-ethanamine

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Technology Process of 2-(4-fluorophenyl)-2-(4,6-dimethyl-2-hydroxyphenyl)-N-(4-methylphenylsulfonyl)-ethanamine

There total 1 articles about 2-(4-fluorophenyl)-2-(4,6-dimethyl-2-hydroxyphenyl)-N-(4-methylphenylsulfonyl)-ethanamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 141120-61-8
tris-(3,5-dimethylphenyl) borate

: 250260-25-4
2-(4-fluoro-phenyl)-1-(toluene-4-sulfonyl)-aziridine

: 897960-96-2
2-(4-fluorophenyl)-2-(4,6-dimethyl-2-hydroxyphenyl)-N-(4-methylphenylsulfonyl)-ethanamine

Guidance literature:: In dichloromethane; at -78 ℃; for 24h;
DOI:10.1021/ol060822m

Reference yield: 81.0%

: 897960-96-2
2-(4-fluorophenyl)-2-(4,6-dimethyl-2-hydroxyphenyl)-N-(4-methylphenylsulfonyl)-ethanamine

: 407-25-0
trifluoroacetic anhydride

: 2-(4-fluorophenyl)-2-(4,6-dimethyl-2-trifluoromethanesulfonyloxyphenyl)-N-(4-methylphenylsulfonyl)-ethanamine

Guidance literature:: With pyridine; at 20 ℃; for 2h;
DOI:10.1021/ol060822m

Reference yield:

: 897960-96-2
2-(4-fluorophenyl)-2-(4,6-dimethyl-2-hydroxyphenyl)-N-(4-methylphenylsulfonyl)-ethanamine

: 4,6-dimethyl-3-(4-fluorophenyl)-1-(4-methylphenylsulfonyl)-indoline

Guidance literature:: Multi-step reaction with 2 steps

1: 81 percent / pyridine / 2 h / 20 °C

2: 90 percent / CsOAc; CuI / dimethylsulfoxide / 12 h / 120 °C

With pyridine; copper(l) iodide; cesium acetate; In dimethyl sulfoxide;
DOI:10.1021/ol060822m