cyclo-[Orn(Nα-6-heptyloxy-2-naphthoyl)-Thr-Pro(4S-N3)-hTyr-Lys(Nε-Cbz)-Pro(4S-N3)]

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Chemical Name:cyclo-[Orn(Nα-6-heptyloxy-2-naphthoyl)-Thr-Pro(4S-N3)-hTyr-Lys(Nε-Cbz)-Pro(4S-N3)]
CAS No.:1371578-14-1
Molecular Formula:C₆₁H₇₈N₁₄O₁₂
Molecular Weight:1199.38
Hs Code.:

Synonyms:cyclo-[Orn(Nα-6-heptyloxy-2-naphthoyl)-Thr-Pro(4S-N3)-hTyr-Lys(Nε-Cbz)-Pro(4S-N3)]

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Chemical Property of cyclo-[Orn(Nα-6-heptyloxy-2-naphthoyl)-Thr-Pro(4S-N3)-hTyr-Lys(Nε-Cbz)-Pro(4S-N3)]

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Technology Process of cyclo-[Orn(Nα-6-heptyloxy-2-naphthoyl)-Thr-Pro(4S-N3)-hTyr-Lys(Nε-Cbz)-Pro(4S-N3)]

There total 10 articles about cyclo-[Orn(Nα-6-heptyloxy-2-naphthoyl)-Thr-Pro(4S-N3)-hTyr-Lys(Nε-Cbz)-Pro(4S-N3)] which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 84520-69-4
methyl (2S,4S)-4-azidopyrrolidine-2-carboxylate

: 1371578-14-1
cyclo-[Orn(Nα-6-heptyloxy-2-naphthoyl)-Thr-Pro(4S-N3)-hTyr-Lys(Nε-Cbz)-Pro(4S-N3)]

Guidance literature:: Multi-step reaction with 4 steps

1.1: benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine / dichloromethane / 0.67 h / 0 °C

1.2: 24.5 h / 0 - 20 °C

2.1: trifluoroacetic acid / dichloromethane / 0.67 h / 20 °C

2.2: 24.67 h / 0 - 20 °C

3.1: sodium hydroxide / ethanol; water / 20 °C

3.2: pH 4.5

4.1: benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / dichloromethane / 10 h / 20 °C

4.2: 1 h / 20 °C

With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; sodium hydroxide; In ethanol; dichloromethane; water;
DOI:10.1016/j.tet.2012.02.015

Reference yield:

: C₂₀H₃₅N₇O₇

: 1371578-14-1
cyclo-[Orn(Nα-6-heptyloxy-2-naphthoyl)-Thr-Pro(4S-N3)-hTyr-Lys(Nε-Cbz)-Pro(4S-N3)]

Guidance literature:: Multi-step reaction with 3 steps

1.1: N,N-dimethyl-formamide / 24 h / 20 °C

2.1: trifluoroacetic acid / dichloromethane / 0.75 h / 20 °C

3.1: benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / dichloromethane / 10 h / 20 °C

3.2: 1 h / 20 °C

With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.tet.2012.02.015

Reference yield:

: 1203557-70-3
Nα-Boc-Lys(Nε-Cbz)-Pro(4S-N3)-OMe

: 1371578-14-1
cyclo-[Orn(Nα-6-heptyloxy-2-naphthoyl)-Thr-Pro(4S-N3)-hTyr-Lys(Nε-Cbz)-Pro(4S-N3)]

Guidance literature:: Multi-step reaction with 3 steps

1.1: trifluoroacetic acid / dichloromethane / 0.67 h / 20 °C

1.2: 24.67 h / 0 - 20 °C

2.1: sodium hydroxide / ethanol; water / 20 °C

2.2: pH 4.5

3.1: benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / dichloromethane / 10 h / 20 °C

3.2: 1 h / 20 °C

With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; sodium hydroxide; In ethanol; dichloromethane; water;
DOI:10.1016/j.tet.2012.02.015