1-(2,5-Dihydroxy-phenyl)-3-(3-nitro-phenyl)-propane-1,3-dione

Base Information

• Chemical Name: 1-(2,5-Dihydroxy-phenyl)-3-(3-nitro-phenyl)-propane-1,3-dione
• CAS No.: 158555-10-3
• Molecular Formula: C₁₅H₁₁NO₆
• Molecular Weight: 301.255
• Mol file: 158555-10-3.mol

Synonyms:1-(2,5-Dihydroxy-phenyl)-3-(3-nitro-phenyl)-propane-1,3-dione

Chemical Property of 1-(2,5-Dihydroxy-phenyl)-3-(3-nitro-phenyl)-propane-1,3-dione

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-(2,5-Dihydroxy-phenyl)-3-(3-nitro-phenyl)-propane-1,3-dione

There total 1 articles about 1-(2,5-Dihydroxy-phenyl)-3-(3-nitro-phenyl)-propane-1,3-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2,5-Dihydroxyacetophenone (490-78-8) + m-nitrobenzoic acid chloride (121-90-4) → 1-(2,5-Dihydroxy-phenyl)-3-(3-nitro-phenyl)-propane-1,3-dione (158555-10-3)

Guidance literature:

With lithium hexamethyldisilazane; Multistep reaction; 1.) THF, 078 deg C, 2 h, 2.) THF, a) -78 deg C, 1 h, b) RT, 20 h;

DOI:10.1021/jm00046a020

Reference yield:

1-(2,5-Dihydroxy-phenyl)-3-(3-nitro-phenyl)-propane-1,3-dione (158555-10-3) → 6-hydroxy-3',5,7-triaminoflavone

Guidance literature:

Multi-step reaction with 3 steps

1: H₂SO₄, glacial acetic acid / 1 h / 95 - 100 °C

2: 62 percent / nitric acid, glacial acetic acid / 6 h / 60 °C

3: hydrogen / 5percent Pd/C / tetrahydrofuran / 20 h / 2068.6 Torr

With sulfuric acid; hydrogen; nitric acid; acetic acid; palladium on activated charcoal; In tetrahydrofuran;

DOI:10.1021/jm00046a020

Reference yield:

1-(2,5-Dihydroxy-phenyl)-3-(3-nitro-phenyl)-propane-1,3-dione (158555-10-3) → 6-hydroxy-3'-nitroflavone

Guidance literature:

With sulfuric acid; acetic acid; at 95 - 100 ℃; for 1h; Yield given;

DOI:10.1021/jm00046a020

upstream raw materials:

2,5-Dihydroxyacetophenone

m-nitrobenzoic acid chloride

Downstream raw materials:

6-hydroxy-3',5,7-trinitroflavone