biphenyl-2-ylcarbamic acid 1-(2-{[3-(3-{2-[(R)-2-hydroxy-2-(8-hydroxy-2-oxo-1,2-dihydroquinolin-5-yl)ethylamino]ethyl}phenylcarbamoyl)-propyl]methylcarbamoyl}ethyl)piperidin-4-yl ester

Base Information

Chemical Name:biphenyl-2-ylcarbamic acid 1-(2-{[3-(3-{2-[(R)-2-hydroxy-2-(8-hydroxy-2-oxo-1,2-dihydroquinolin-5-yl)ethylamino]ethyl}phenylcarbamoyl)-propyl]methylcarbamoyl}ethyl)piperidin-4-yl ester
CAS No.:1253580-03-8
Molecular Formula:C₄₅H₅₂N₆O₇
Molecular Weight:788.944
Hs Code.:

biphenyl-2-ylcarbamic acid 1-(2-{[3-(3-{2-[(R)-2-hydroxy-2-(8-hydroxy-2-oxo-1,2-dihydroquinolin-5-yl)ethylamino]ethyl}phenylcarbamoyl)-propyl]methylcarbamoyl}ethyl)piperidin-4-yl ester

Synonyms:biphenyl-2-ylcarbamic acid 1-(2-{[3-(3-{2-[(R)-2-hydroxy-2-(8-hydroxy-2-oxo-1,2-dihydroquinolin-5-yl)ethylamino]ethyl}phenylcarbamoyl)-propyl]methylcarbamoyl}ethyl)piperidin-4-yl ester

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Chemical Property of biphenyl-2-ylcarbamic acid 1-(2-{[3-(3-{2-[(R)-2-hydroxy-2-(8-hydroxy-2-oxo-1,2-dihydroquinolin-5-yl)ethylamino]ethyl}phenylcarbamoyl)-propyl]methylcarbamoyl}ethyl)piperidin-4-yl ester

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Technology Process of biphenyl-2-ylcarbamic acid 1-(2-{[3-(3-{2-[(R)-2-hydroxy-2-(8-hydroxy-2-oxo-1,2-dihydroquinolin-5-yl)ethylamino]ethyl}phenylcarbamoyl)-propyl]methylcarbamoyl}ethyl)piperidin-4-yl ester

There total 13 articles about biphenyl-2-ylcarbamic acid 1-(2-{[3-(3-{2-[(R)-2-hydroxy-2-(8-hydroxy-2-oxo-1,2-dihydroquinolin-5-yl)ethylamino]ethyl}phenylcarbamoyl)-propyl]methylcarbamoyl}ethyl)piperidin-4-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 47.0%

: 1253582-11-4
biphenyl-2-ylcarbamic acid 1-(2-{[3-(3-{2-[(R)-2-(tert-butyldimethylsilanyloxy)-2-(8-hydroxy-2-oxo-1,2-dihydroquinolin-5-yl)ethylamino]-ethyl}phenylcarbamoyl)propyl]methylcarbamoyl}ethyl)piperidin-4-yl ester

: 1253580-03-8
biphenyl-2-ylcarbamic acid 1-(2-{[3-(3-{2-[(R)-2-hydroxy-2-(8-hydroxy-2-oxo-1,2-dihydroquinolin-5-yl)ethylamino]ethyl}phenylcarbamoyl)-propyl]methylcarbamoyl}ethyl)piperidin-4-yl ester

Guidance literature:: With triethylamine tris(hydrogen fluoride); In dichloromethane;

Reference yield:

: 743460-36-8
3-[4-[(2-phenylphenyl)carbamoyloxy]-1-piperidyl]propanoic acid

: 1253580-03-8
biphenyl-2-ylcarbamic acid 1-(2-{[3-(3-{2-[(R)-2-hydroxy-2-(8-hydroxy-2-oxo-1,2-dihydroquinolin-5-yl)ethylamino]ethyl}phenylcarbamoyl)-propyl]methylcarbamoyl}ethyl)piperidin-4-yl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 2,6-dimethylpyridine; 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 20 °C

2: hydrogen; acetic acid / palladium(II) hydroxide / methanol; water / 6 h / 20 °C / Inert atmosphere

3: triethylamine tris(hydrogen fluoride) / dichloromethane

With 2,6-dimethylpyridine; 1-hydroxy-7-aza-benzotriazole; hydrogen; acetic acid; triethylamine tris(hydrogen fluoride); 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; palladium(II) hydroxide; In methanol; dichloromethane; water; N,N-dimethyl-formamide;

Reference yield:

: 1253582-05-6
2-[3-(tritylamino)phenyl]ethanol

: 1253580-03-8
biphenyl-2-ylcarbamic acid 1-(2-{[3-(3-{2-[(R)-2-hydroxy-2-(8-hydroxy-2-oxo-1,2-dihydroquinolin-5-yl)ethylamino]ethyl}phenylcarbamoyl)-propyl]methylcarbamoyl}ethyl)piperidin-4-yl ester

Guidance literature:: Multi-step reaction with 8 steps

1.1: 1,4-diaza-bicyclo[2.2.2]octane / dichloromethane / 0.75 h / 0 °C / Inert atmosphere

2.1: sodium hydrogencarbonate / acetonitrile / 18 h / 75 °C / Inert atmosphere

3.1: hydrogenchloride; water / acetonitrile / 1 h / 20 °C / pH < 2 / Inert atmosphere

3.2: pH 7 - 8

4.1: 2,6-dimethylpyridine; 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 20 °C

5.1: trifluoroacetic acid / dichloromethane / 20 °C

6.1: 2,6-dimethylpyridine; 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 20 °C

7.1: hydrogen; acetic acid / palladium(II) hydroxide / methanol; water / 6 h / 20 °C / Inert atmosphere

8.1: triethylamine tris(hydrogen fluoride) / dichloromethane

With 1,4-diaza-bicyclo[2.2.2]octane; 2,6-dimethylpyridine; hydrogenchloride; 1-hydroxy-7-aza-benzotriazole; water; hydrogen; sodium hydrogencarbonate; acetic acid; triethylamine tris(hydrogen fluoride); 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; trifluoroacetic acid; palladium(II) hydroxide; In methanol; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile;