2-(4-morpholinyl)ethyl 5-cyano-1,4-dihydro-6-methyl-2-<(phenylthio)methyl>-4-<2-(trifluoromethyl)phenyl>-3-pyridinecarboxylate

Base Information

Chemical Name:2-(4-morpholinyl)ethyl 5-cyano-1,4-dihydro-6-methyl-2-<(phenylthio)methyl>-4-<2-(trifluoromethyl)phenyl>-3-pyridinecarboxylate
CAS No.:134969-21-4
Molecular Formula:C₂₈H₂₈F₃N₃O₃S
Molecular Weight:543.61
Hs Code.:

Synonyms:2-(4-morpholinyl)ethyl 5-cyano-1,4-dihydro-6-methyl-2-<(phenylthio)methyl>-4-<2-(trifluoromethyl)phenyl>-3-pyridinecarboxylate

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Chemical Property of 2-(4-morpholinyl)ethyl 5-cyano-1,4-dihydro-6-methyl-2-<(phenylthio)methyl>-4-<2-(trifluoromethyl)phenyl>-3-pyridinecarboxylate

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Technology Process of 2-(4-morpholinyl)ethyl 5-cyano-1,4-dihydro-6-methyl-2-<(phenylthio)methyl>-4-<2-(trifluoromethyl)phenyl>-3-pyridinecarboxylate

There total 4 articles about 2-(4-morpholinyl)ethyl 5-cyano-1,4-dihydro-6-methyl-2-<(phenylthio)methyl>-4-<2-(trifluoromethyl)phenyl>-3-pyridinecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 88488-47-5
2-bromoethyl acetoacetate

: 134969-21-4
2-(4-morpholinyl)ethyl 5-cyano-1,4-dihydro-6-methyl-2-<(phenylthio)methyl>-4-<2-(trifluoromethyl)phenyl>-3-pyridinecarboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: Br₂ / CHCl₃ / 16 h / 23 °C

2: Et₃N / 4 h

3: 0.4 g / ethanol / 16 h / Heating

4: acetonitrile / 2 h / Ambient temperature

With bromine; triethylamine; In ethanol; chloroform; acetonitrile;
DOI:10.1021/jm00111a047

Reference yield:

: 32807-10-6
4-Bromo-3-oxo-butyric acid 2-bromo-ethyl ester

: 134969-21-4
2-(4-morpholinyl)ethyl 5-cyano-1,4-dihydro-6-methyl-2-<(phenylthio)methyl>-4-<2-(trifluoromethyl)phenyl>-3-pyridinecarboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: Et₃N / 4 h

2: 0.4 g / ethanol / 16 h / Heating

3: acetonitrile / 2 h / Ambient temperature

With triethylamine; In ethanol; acetonitrile;
DOI:10.1021/jm00111a047

Reference yield:

: 134969-45-2
2-bromoethyl 4-(phenylthio)acetoacetate

: 134969-21-4
2-(4-morpholinyl)ethyl 5-cyano-1,4-dihydro-6-methyl-2-<(phenylthio)methyl>-4-<2-(trifluoromethyl)phenyl>-3-pyridinecarboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: 0.4 g / ethanol / 16 h / Heating

2: acetonitrile / 2 h / Ambient temperature

In ethanol; acetonitrile;
DOI:10.1021/jm00111a047