tert-butyl syn-2-hydroxy-3-phenyl-3-(tosylamino)propanoate

Base Information

• Chemical Name: tert-butyl syn-2-hydroxy-3-phenyl-3-(tosylamino)propanoate
• CAS No.: 203176-12-9
• Molecular Formula: C₂₀H₂₅NO₅S
• Molecular Weight: 391.488
• Mol file: 203176-12-9.mol

Synonyms:tert-butyl syn-2-hydroxy-3-phenyl-3-(tosylamino)propanoate

Chemical Property of tert-butyl syn-2-hydroxy-3-phenyl-3-(tosylamino)propanoate

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of tert-butyl syn-2-hydroxy-3-phenyl-3-(tosylamino)propanoate

There total 3 articles about tert-butyl syn-2-hydroxy-3-phenyl-3-(tosylamino)propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

tert-butyl cinnamate (14990-09-1) + rac-2,3-bis(tosylamino)-succinic acid → tert-butyl syn-3-hydroxy-3-phenyl-2-(tosylamino)propanoate + tert-butyl syn-2-hydroxy-3-phenyl-3-(tosylamino)propanoate (203176-12-9)

Guidance literature:

rac-2,3-bis(tosylamino)-succinic acid; With potassium carbonate; K2; In water; tert-butyl alcohol; at 20 ℃; for 0.25h;

tert-butyl cinnamate; With chloroamine-T; In water; tert-butyl alcohol; at 20 ℃; for 20h; Title compound not separated from byproducts;

DOI:10.1002/adsc.200606054

Reference yield:

(S)-N,N'-bistosyl-2,3-diaminopropionic acid + tert-butyl cinnamate (14990-09-1) → tert-butyl syn-3-hydroxy-3-phenyl-2-(tosylamino)propanoate + tert-butyl syn-2-hydroxy-3-phenyl-3-(tosylamino)propanoate (203176-12-9)

Guidance literature:

(S)-N,N'-bistosyl-2,3-diaminopropionic acid; With potassium carbonate; K2; In water; tert-butyl alcohol; at 20 ℃; for 0.25h;

tert-butyl cinnamate; With chloroamine-T; In water; tert-butyl alcohol; at 20 ℃; for 20h; Title compound not separated from byproducts;

DOI:10.1002/adsc.200606054

Reference yield:

diethyl rac-[2,3-bis(tosylamino)]-succinate → tert-butyl syn-2-hydroxy-3-phenyl-3-(tosylamino)propanoate (203176-12-9)

Guidance literature:

Multi-step reaction with 2 steps

1.1: 57 percent / aq. LiOH / 40 h / 20 °C

2.1: K₂CO₃ / K₂[OsO₂(OH)4] / H₂O; 2-methyl-propan-2-ol / 0.25 h / 20 °C

2.2: chloramine T / H₂O; 2-methyl-propan-2-ol / 20 h / 20 °C

With lithium hydroxide; potassium carbonate; K2; In water; tert-butyl alcohol;

DOI:10.1002/adsc.200606054

upstream raw materials:

tert-butyl cinnamate