(S)-2-(2'-methyl-[1,1'-biphenyl]-4-yl)-6-nitro-2,3-dihydroquinazolin-4(1H)-one

Base Information

Chemical Name:(S)-2-(2'-methyl-[1,1'-biphenyl]-4-yl)-6-nitro-2,3-dihydroquinazolin-4(1H)-one
CAS No.:1044499-65-1
Molecular Formula:C₂₁H₁₇N₃O₃
Molecular Weight:359.384
Hs Code.:

Synonyms:(S)-2-(2'-methyl-[1,1'-biphenyl]-4-yl)-6-nitro-2,3-dihydroquinazolin-4(1H)-one

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Chemical Property of (S)-2-(2'-methyl-[1,1'-biphenyl]-4-yl)-6-nitro-2,3-dihydroquinazolin-4(1H)-one

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Technology Process of (S)-2-(2'-methyl-[1,1'-biphenyl]-4-yl)-6-nitro-2,3-dihydroquinazolin-4(1H)-one

There total 2 articles about (S)-2-(2'-methyl-[1,1'-biphenyl]-4-yl)-6-nitro-2,3-dihydroquinazolin-4(1H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 28144-70-9,88-68-6
anthranilic acid amide

: 108934-21-0
4-(2'-methylphenyl)benzaldehyde

: 1044499-65-1
(S)-2-(2'-methyl-[1,1'-biphenyl]-4-yl)-6-nitro-2,3-dihydroquinazolin-4(1H)-one

Guidance literature:: anthranilic acid amide; With C₇₀H₄₁O₁₂P^(4-)*C₂H₇N*H⁽¹⁺⁾*In⁽³⁺⁾*H₂O*2C₃H₇NO; In chloroform; at 80 ℃; for 0.5h; Schlenk technique;

4-(2'-methylphenyl)benzaldehyde; In chloroform; at 80 ℃; for 20h; enantioselective reaction; Schlenk technique;
DOI:10.1002/anie.201908959

Reference yield: 67.0%

: 1044499-63-9
C₂₂H₁₆F₃N₃O₆S

: 1044499-65-1
(S)-2-(2'-methyl-[1,1'-biphenyl]-4-yl)-6-nitro-2,3-dihydroquinazolin-4(1H)-one

Guidance literature:: With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; formic acid; triethylamine; In N,N-dimethyl-formamide; at 90 ℃;
DOI:10.1021/jm800271c