7-{4-[2-(butoxy)ethoxy]phenyl}-1-isobutyl-N-({4-[(4-methyl-4H-1,2,4-triazol-3-yl)methyl]sulfanyl}phenyl)-2,3-dihydro-1H-1-benzazepine-4-carboxamide

Base Information

Chemical Name:7-{4-[2-(butoxy)ethoxy]phenyl}-1-isobutyl-N-({4-[(4-methyl-4H-1,2,4-triazol-3-yl)methyl]sulfanyl}phenyl)-2,3-dihydro-1H-1-benzazepine-4-carboxamide
CAS No.:497850-26-7
Molecular Formula:C₃₇H₄₅N₅O₃S
Molecular Weight:639.862
Hs Code.:

Synonyms:7-{4-[2-(butoxy)ethoxy]phenyl}-1-isobutyl-N-({4-[(4-methyl-4H-1,2,4-triazol-3-yl)methyl]sulfanyl}phenyl)-2,3-dihydro-1H-1-benzazepine-4-carboxamide

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Chemical Property of 7-{4-[2-(butoxy)ethoxy]phenyl}-1-isobutyl-N-({4-[(4-methyl-4H-1,2,4-triazol-3-yl)methyl]sulfanyl}phenyl)-2,3-dihydro-1H-1-benzazepine-4-carboxamide

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Technology Process of 7-{4-[2-(butoxy)ethoxy]phenyl}-1-isobutyl-N-({4-[(4-methyl-4H-1,2,4-triazol-3-yl)methyl]sulfanyl}phenyl)-2,3-dihydro-1H-1-benzazepine-4-carboxamide

There total 4 articles about 7-{4-[2-(butoxy)ethoxy]phenyl}-1-isobutyl-N-({4-[(4-methyl-4H-1,2,4-triazol-3-yl)methyl]sulfanyl}phenyl)-2,3-dihydro-1H-1-benzazepine-4-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 135206-76-7
3-chloromethyl-1-methyl-1H-[1,2,4]triazole hydrochloride

: 1193-02-8
4-aminotiophenol

: 597583-16-9
7-[4-(2-butoxy-ethoxy)-phenyl]-1-isobutyl-2,3-dihydro-1H-benzo[b]azepine-4-carbonyl chloride

: 497850-26-7
7-{4-[2-(butoxy)ethoxy]phenyl}-1-isobutyl-N-({4-[(4-methyl-4H-1,2,4-triazol-3-yl)methyl]sulfanyl}phenyl)-2,3-dihydro-1H-1-benzazepine-4-carboxamide

Guidance literature:: 4-aminotiophenol; With benzyl chloroformate; triethylamine; In tetrahydrofuran; at -78 - 20 ℃; for 1.16667h;

7-[4-(2-butoxy-ethoxy)-phenyl]-1-isobutyl-2,3-dihydro-1H-benzo[b]azepine-4-carbonyl chloride; In tetrahydrofuran; at 20 ℃; for 1h;

3-chloromethyl-1-methyl-1H-[1,2,4]triazole hydrochloride; more than 3 stages;

Reference yield:

: 130219-46-4
S-<(benzyloxy)carbonyl>-4-aminobenzenethiol

: 135206-76-7
3-chloromethyl-4-methyl-4H-1,2,4-triazole hydrochloride

: 597583-16-9
7-[4-(2-butoxy-ethoxy)-phenyl]-1-isobutyl-2,3-dihydro-1H-benzo[b]azepine-4-carbonyl chloride

: 497850-26-7
7-{4-[2-(butoxy)ethoxy]phenyl}-1-isobutyl-N-({4-[(4-methyl-4H-1,2,4-triazol-3-yl)methyl]sulfanyl}phenyl)-2,3-dihydro-1H-1-benzazepine-4-carboxamide

Guidance literature:: S-<(benzyloxy)carbonyl>-4-aminobenzenethiol; 7-[4-(2-butoxy-ethoxy)-phenyl]-1-isobutyl-2,3-dihydro-1H-benzo[b]azepine-4-carbonyl chloride; With triethylamine; In tetrahydrofuran; at 0 - 20 ℃;

With sodium hydroxide; In tetrahydrofuran; methanol; at 20 ℃;

3-chloromethyl-4-methyl-4H-1,2,4-triazole hydrochloride; In tetrahydrofuran; methanol; at 20 ℃;
DOI:10.1016/j.bmc.2004.10.021

Reference yield:

: 1193-02-8
4-aminotiophenol

: 497850-26-7
7-{4-[2-(butoxy)ethoxy]phenyl}-1-isobutyl-N-({4-[(4-methyl-4H-1,2,4-triazol-3-yl)methyl]sulfanyl}phenyl)-2,3-dihydro-1H-1-benzazepine-4-carboxamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: 97 percent / Et₃N / 0.5 h / -78 °C

2.1: Et₃N / tetrahydrofuran / 0 - 20 °C

2.2: NaOH / methanol; tetrahydrofuran / 20 °C

2.3: methanol; tetrahydrofuran / 20 °C

With triethylamine; In tetrahydrofuran;
DOI:10.1016/j.bmc.2004.10.021