3'-carboethoxy-2-[5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl]methoxy-[1,1'-biphenyl]-6-[(E)-3-propenoic acid], methyl ester

Base Information

Chemical Name:3'-carboethoxy-2-[5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl]methoxy-[1,1'-biphenyl]-6-[(E)-3-propenoic acid], methyl ester
CAS No.:288162-47-0
Molecular Formula:C₃₄H₃₈O₅
Molecular Weight:526.673
Hs Code.:

Synonyms:3'-carboethoxy-2-[5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl]methoxy-[1,1'-biphenyl]-6-[(E)-3-propenoic acid], methyl ester

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Chemical Property of 3'-carboethoxy-2-[5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl]methoxy-[1,1'-biphenyl]-6-[(E)-3-propenoic acid], methyl ester

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Technology Process of 3'-carboethoxy-2-[5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl]methoxy-[1,1'-biphenyl]-6-[(E)-3-propenoic acid], methyl ester

There total 4 articles about 3'-carboethoxy-2-[5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl]methoxy-[1,1'-biphenyl]-6-[(E)-3-propenoic acid], methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

: 21204-67-1,2605-67-6
methyl (triphenylphosphoranylidene)acetate

: 163117-74-6
2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)methoxy-[1,1'-biphenyl]-3'-carboethoxy-6-carboxaldehyde

: 288162-47-0
3'-carboethoxy-2-[5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl]methoxy-[1,1'-biphenyl]-6-[(E)-3-propenoic acid], methyl ester

Guidance literature:: In dichloromethane; at 20 ℃; for 44h;
DOI:10.1016/S0968-0896(00)00047-X

Reference yield:

: 24677-78-9
2,3-dihydroxybenzaldehyde

: 288162-47-0
3'-carboethoxy-2-[5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl]methoxy-[1,1'-biphenyl]-6-[(E)-3-propenoic acid], methyl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydride; DMSO / 1 h / 20 °C

1.2: 44 percent / dimethylsulfoxide / 20 °C

2.1: 47 percent / 4-dimethylaminopyridine / CH₂Cl₂ / 0.5 h / 0 °C

3.1: 77 percent / bis(triphenylphosphine)palladium dichloride; LiCl / dimethylformamide / 2.75 h / 150 °C

4.1: 64 percent / CH₂Cl₂ / 44 h / 20 °C

With dmap; bis-triphenylphosphine-palladium(II) chloride; sodium hydride; dimethyl sulfoxide; lithium chloride; In dichloromethane; N,N-dimethyl-formamide; 1.1: deprotonation / 1.2: Substitution / 2.1: trifluoromethylsulphonylation / 3.1: Condensation / 4.1: Wittig olefination;
DOI:10.1016/S0968-0896(00)00047-X

Reference yield:

: 163117-72-4
3-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)methoxy-salicylaldehyde

: 288162-47-0
3'-carboethoxy-2-[5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl]methoxy-[1,1'-biphenyl]-6-[(E)-3-propenoic acid], methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 47 percent / 4-dimethylaminopyridine / CH₂Cl₂ / 0.5 h / 0 °C

2: 77 percent / bis(triphenylphosphine)palladium dichloride; LiCl / dimethylformamide / 2.75 h / 150 °C

3: 64 percent / CH₂Cl₂ / 44 h / 20 °C

With dmap; bis-triphenylphosphine-palladium(II) chloride; lithium chloride; In dichloromethane; N,N-dimethyl-formamide; 1: trifluoromethylsulphonylation / 2: Condensation / 3: Wittig olefination;
DOI:10.1016/S0968-0896(00)00047-X