ANTI-2-BENZYL-2-AZABICYCLO[2.2.1]HEPTANE-7-CARBOXYLIC ACID ETHYL ESTER

Base Information

• Chemical Name: ANTI-2-BENZYL-2-AZABICYCLO[2.2.1]HEPTANE-7-CARBOXYLIC ACID ETHYL ESTER
• CAS No.: 745836-32-2
• Molecular Formula: C₁₆H₂₁NO₂
• Molecular Weight: 259.348
• Mol file: 745836-32-2.mol

Synonyms:ANTI-2-BENZYL-2-AZABICYCLO[2.2.1]HEPTANE-7-CARBOXYLIC ACID ETHYL ESTER

Chemical Property of ANTI-2-BENZYL-2-AZABICYCLO[2.2.1]HEPTANE-7-CARBOXYLIC ACID ETHYL ESTER

Chemical Property:

• Vapor Pressure: 7.39E-05mmHg at 25°C
• Refractive Index: 1.56
• Boiling Point: 342.7°C at 760 mmHg
• Flash Point: 117.4°C
• PSA: 29.54000
• Density: 1.133g/cm³
• LogP: 2.39800

Purity/Quality:

98%min ^*data from raw suppliers

Ethyl (1S,4R)-3-benzyl-3-azabicyclo[2.2.1]heptane-7-carboxylate >95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of ANTI-2-BENZYL-2-AZABICYCLO[2.2.1]HEPTANE-7-CARBOXYLIC ACID ETHYL ESTER

There total 13 articles about ANTI-2-BENZYL-2-AZABICYCLO[2.2.1]HEPTANE-7-CARBOXYLIC ACID ETHYL ESTER which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 46.0%

anti-2-benzyl-2-azabicyclo[2.2.1]heptane-7-carboxylic acid ethyl ester (745836-32-2) → syn-2-benzyl-2-azabicyclo[2.2.1]heptane-7-carboxylic acid ethyl ester (745836-32-2)

Guidance literature:

With N,N,N,N,N,N-hexamethylphosphoric triamide; sodium ethanolate; In ethanol; at 65 ℃; for 24h;

DOI:10.1021/jo0492564

Reference yield:

N-benzyl-2-azanorborn-5-ene (112375-05-0,150851-98-2) → syn-2-benzyl-2-azabicyclo[2.2.1]heptane-7-carboxylic acid ethyl ester (745836-32-2)

Guidance literature:

Multi-step reaction with 7 steps

1: Br₂ / CH₂Cl₂; acetonitrile / -78 - 20 °C

2: 93 percent / Red-Al / toluene; tetrahydrofuran / 2 h / -10 °C

3: 66 percent / 18-crown-6 / dimethylformamide / 24 h / 110 °C

4: HCl / H₂O / 65 h / 90 °C

5: SOCl₂ / 6 h / 40 °C

6: 0.5 h / 20 °C

7: 46 percent / NaOEt; HMPA / ethanol / 24 h / 65 °C

With hydrogenchloride; N,N,N,N,N,N-hexamethylphosphoric triamide; thionyl chloride; 18-crown-6 ether; bromine; sodium ethanolate; sodium bis(2-methoxyethoxy)aluminium dihydride; In tetrahydrofuran; ethanol; dichloromethane; water; N,N-dimethyl-formamide; toluene; acetonitrile;

DOI:10.1021/jo0492564

Reference yield:

N-benzyl-2-azanorborn-5-ene (112375-05-0,150851-98-2) → anti-2-benzyl-2-azabicyclo[2.2.1]heptane-7-carboxylic acid ethyl ester (745836-32-2)

Guidance literature:

Multi-step reaction with 6 steps

1: Br₂ / CH₂Cl₂; acetonitrile / -78 - 20 °C

2: 93 percent / Red-Al / toluene; tetrahydrofuran / 2 h / -10 °C

3: 66 percent / 18-crown-6 / dimethylformamide / 24 h / 110 °C

4: HCl / H₂O / 65 h / 90 °C

5: SOCl₂ / 6 h / 40 °C

6: 0.5 h / 20 °C

With hydrogenchloride; thionyl chloride; 18-crown-6 ether; bromine; sodium bis(2-methoxyethoxy)aluminium dihydride; In tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide; toluene; acetonitrile;

DOI:10.1021/jo0492564

upstream raw materials:

N-benzyl-2-azanorborn-5-ene

anti-7-bromo-2-benzyl-2-azabicyclo[2.2.1]heptane

anti-7-cyano-2-benzyl-2-azabicyclo[2.2.1]heptane

3-bromo-1-benzyl-1-azoniatricyclo[2.2.1.0^2,6]heptane bromide

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 745836-32-2 ANTI-2-BENZYL-2-AZABICYCLO[2.2.1]HEPTANE-7-CARBOXYLIC ACID ETHYL ESTER

Send

Send

Metric Ton KG G Pound L ML

Send

Send