(4S,5R)-2-(4-tert-butyl-2-ethoxyphenyl)-4,5-bis(4-chlorophenyl)-4,5-dihydro-1H-imidazole

Base Information

• Chemical Name: (4S,5R)-2-(4-tert-butyl-2-ethoxyphenyl)-4,5-bis(4-chlorophenyl)-4,5-dihydro-1H-imidazole
• CAS No.: 870007-53-7
• Molecular Formula: C₂₇H₂₈Cl₂N₂O
• Molecular Weight: 467.438
• Mol file: 870007-53-7.mol

Synonyms:(4S,5R)-2-(4-tert-butyl-2-ethoxyphenyl)-4,5-bis(4-chlorophenyl)-4,5-dihydro-1H-imidazole

Chemical Property of (4S,5R)-2-(4-tert-butyl-2-ethoxyphenyl)-4,5-bis(4-chlorophenyl)-4,5-dihydro-1H-imidazole

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (4S,5R)-2-(4-tert-butyl-2-ethoxyphenyl)-4,5-bis(4-chlorophenyl)-4,5-dihydro-1H-imidazole

There total 7 articles about (4S,5R)-2-(4-tert-butyl-2-ethoxyphenyl)-4,5-bis(4-chlorophenyl)-4,5-dihydro-1H-imidazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

4-(tert-butyl)-2-ethoxy-benzoic acid methyl ester (870007-39-9) + (1R,2S)-1,2-bis(4-chlorophenyl)ethane-1,2-diamine (86212-34-2,91044-20-1,98674-96-5,74641-30-8) → (4S,5R)-2-(4-tert-butyl-2-ethoxyphenyl)-4,5-bis(4-chlorophenyl)-4,5-dihydro-1H-imidazole (870007-53-7)

Guidance literature:

With trimethylaluminum; In toluene; Reflux;

DOI:10.1021/op300254q

Reference yield:

4-(tert-butyl)-2-ethoxy-benzoic acid methyl ester (870007-39-9) → (4S,5R)-2-(4-tert-butyl-2-ethoxyphenyl)-4,5-bis(4-chlorophenyl)-4,5-dihydro-1H-imidazole (870007-53-7)

Guidance literature:

(1R,2S)-1,2-bis(4-chlorophenyl)ethane-1,2-diamine; trimethylaluminum; In toluene; at 0 - 90 ℃; for 1.75h;

4-(tert-butyl)-2-ethoxy-benzoic acid methyl ester; In toluene; at 60 ℃; for 3h; Heating / reflux;

With rochelle salt; In ethyl acetate; toluene; at 10 - 20 ℃;

Reference yield:

2-iodo-5-(1,1-dimethylethyl)phenol (20942-70-5) → (4S,5R)-2-(4-tert-butyl-2-ethoxyphenyl)-4,5-bis(4-chlorophenyl)-4,5-dihydro-1H-imidazole (870007-53-7)

Guidance literature:

Multi-step reaction with 3 steps

1.1: potassium carbonate / ethanol / Heating / reflux

2.1: triethylamine / bis-triphenylphosphine-palladium(II) chloride / DMF (N,N-dimethyl-formamide) / 65 °C / 2068.65 Torr

3.1: trimethylaluminum / toluene / 1.75 h / 0 - 90 °C

3.2: 3 h / 60 °C / Heating / reflux

3.3: 10 - 20 °C

With potassium carbonate; triethylamine; bis-triphenylphosphine-palladium(II) chloride; trimethylaluminum; In DMF (N,N-dimethyl-formamide); ethanol; toluene;

upstream raw materials:

4-(tert-butyl)-2-ethoxy-benzoic acid methyl ester

(1R,2S)-1,2-bis(4-chlorophenyl)ethane-1,2-diamine

4-tert-butyl-2-ethoxy-1-iodo-benzene

3-tert-butylphenyol

Downstream raw materials:

2-{4-[(4S,5R)-2-(4-tert-butyl-2-ethoxy-phenyl)-4,5-bis-(4-chloro-phenyl)-4,5-dihydro-imidazole-1-carbonyl]-piperazin-1-yl}-1-morpholin-4-yl-ethanone

2-{4-[(4S,5R)-2-(4-tert-butyl-2-ethoxy-phenyl)-4,5-bis-(4-chloro-phenyl)-4,5-dihydro-imidazole-1-carbonyl]-piperazin-1-yl}-1-morpholin-4-yl-ethanone hydrochloride