1-(6-ethoxycarbonyl-2-benzothiazolyl)-3-ethylurea

Base Information

• Chemical Name: 1-(6-ethoxycarbonyl-2-benzothiazolyl)-3-ethylurea
• CAS No.: 352528-33-7
• Molecular Formula: C₁₃H₁₅N₃O₃S
• Molecular Weight: 293.346
• Mol file: 352528-33-7.mol

Synonyms:1-(6-ethoxycarbonyl-2-benzothiazolyl)-3-ethylurea

Chemical Property of 1-(6-ethoxycarbonyl-2-benzothiazolyl)-3-ethylurea

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-(6-ethoxycarbonyl-2-benzothiazolyl)-3-ethylurea

There total 1 articles about 1-(6-ethoxycarbonyl-2-benzothiazolyl)-3-ethylurea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

ethyl 2-aminobenzothiazole-6-carboxylate (50850-93-6) + ethyl isocyanate (109-90-0) → 1-(6-ethoxycarbonyl-2-benzothiazolyl)-3-ethylurea (352528-33-7) + 1-(6-benzyl-2-benzothiazolyl)-3-ethylurea (352527-96-9)

Guidance literature:

With triethylamine; In toluene;

Reference yield:

1-(6-ethoxycarbonyl-2-benzothiazolyl)-3-ethylurea (352528-33-7) → 2-(3-ethyl-ureido)-benzothiazole-6-carboxylic acid (5-amino-2-methyl-phenyl)-amide (1024583-36-5)

Guidance literature:

Multi-step reaction with 3 steps

1: lithium hydroxide; water / 1,4-dioxane / 6 h / 60 °C

2: triethylamine; HATU / N,N-dimethyl-formamide / 20 °C

3: trifluoroacetic acid / 1 h

With lithium hydroxide; water; triethylamine; HATU; trifluoroacetic acid; In 1,4-dioxane; N,N-dimethyl-formamide;

Reference yield:

1-(6-ethoxycarbonyl-2-benzothiazolyl)-3-ethylurea (352528-33-7) → (3-{[2-(3-ethyl-ureido)-benzothiazole-6-carbonyl]-amino}-4-methyl-phenyl)-carbamic acid tert-butyl ester (1024583-35-4)

Guidance literature:

Multi-step reaction with 2 steps

1: lithium hydroxide; water / 1,4-dioxane / 6 h / 60 °C

2: triethylamine; HATU / N,N-dimethyl-formamide / 20 °C

With lithium hydroxide; water; triethylamine; HATU; In 1,4-dioxane; N,N-dimethyl-formamide;

upstream raw materials:

ethyl 2-aminobenzothiazole-6-carboxylate

ethyl isocyanate

Downstream raw materials:

2-(3-ethyl-ureido)-benzothiazole-6-carboxylic acid (5-amino-2-methyl-phenyl)-amide

(3-{[2-(3-ethyl-ureido)-benzothiazole-6-carbonyl]-amino}-4-methyl-phenyl)-carbamic acid tert-butyl ester

2-(3-ethyl-ureido)-benzothiazole-6-carboxylic acid [2-methyl-5-(3-methyl-benzoylamino)-phenyl]-amide

Refernces