(R)-N-tert-butoxycarbonyl-4-benzoylphenylalaninol

Base Information

Chemical Name:(R)-N-tert-butoxycarbonyl-4-benzoylphenylalaninol
CAS No.:885022-17-3
Molecular Formula:C₂₁H₂₅NO₄
Molecular Weight:355.434
Hs Code.:

Synonyms:(R)-N-tert-butoxycarbonyl-4-benzoylphenylalaninol

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (R)-N-tert-butoxycarbonyl-4-benzoylphenylalaninol

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Technology Process of (R)-N-tert-butoxycarbonyl-4-benzoylphenylalaninol

There total 2 articles about (R)-N-tert-butoxycarbonyl-4-benzoylphenylalaninol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 885022-10-6
(R)-N-tert-butoxycarbonyl-4-benzoylphenylalaninol acetic acid ester

: 885022-17-3
(R)-N-tert-butoxycarbonyl-4-benzoylphenylalaninol

Guidance literature:: With sodium hydroxide; In methanol; at 20 ℃; for 4h;
DOI:10.1021/jm051226l

Reference yield:

: 591-50-4
iodobenzene

: 885022-17-3
(R)-N-tert-butoxycarbonyl-4-benzoylphenylalaninol

Guidance literature:: Multi-step reaction with 2 steps

1: 79 percent / PdCl₂; PPh₃ / dimethylformamide / 8 h / 90 °C

2: 93 percent / aq. NaOH / methanol / 4 h / 20 °C

With sodium hydroxide; triphenylphosphine; palladium dichloride; In methanol; N,N-dimethyl-formamide;
DOI:10.1021/jm051226l