1-(4-Fluorobenzyl)-N-piperidin-4-yl-1H-benzimidazol-2-amine dihydrobromide

Base Information

Chemical Name:1-(4-Fluorobenzyl)-N-piperidin-4-yl-1H-benzimidazol-2-amine dihydrobromide
CAS No.:75970-64-8
Molecular Formula:C19H21 F N4 . 2 Br H
Molecular Weight:486.225
Hs Code.:
European Community (EC) Number:278-353-7
DSSTox Substance ID:DTXSID90997334
ChEMBL ID:CHEMBL1788380
Mol file:75970-64-8.mol

Synonyms:1-((4-flurophenyl)methyl)-N-4-piperidinyl-1H-benzimidazol-2-amine;norastemizole;norastemizole hydrobromide;tecastemizole

Suppliers and Price of 1-(4-Fluorobenzyl)-N-piperidin-4-yl-1H-benzimidazol-2-amine dihydrobromide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
NorastemizoleHydrobromide
500 mg
$ 1455.00

TRC
NorastemizoleHydrobromide
50 mg
$ 185.00

Total 8 raw suppliers

Chemical Property of 1-(4-Fluorobenzyl)-N-piperidin-4-yl-1H-benzimidazol-2-amine dihydrobromide

Chemical Property:

Vapor Pressure:6.62E-11mmHg at 25°C
Melting Point:170-178?C
Boiling Point:519.8°C at 760 mmHg
Flash Point:268.2°C
PSA：41.88000
LogP:5.70560
Storage Temp.:Refrigerator
Solubility.:Methanol (Slightly), Water (Slightly)
Hydrogen Bond Donor Count:4
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:4
Exact Mass:486.02530
Heavy Atom Count:26
Complexity:393

Purity/Quality:

99.90% ^*data from raw suppliers

NorastemizoleHydrobromide ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1CNCCC1NC2=NC3=CC=CC=C3N2CC4=CC=C(C=C4)F.Br.Br
Uses 1-(4-fluorobenzyl)-N-piperidin-4-yl-1H-benzimidazol-2-amine dihydrobromide is An antihistamine used to treat allergic rhinitis and asthma which does not induce adverse effects such as cardiac arrhythmia, fatigue, or general body weakness.

Technology Process of 1-(4-Fluorobenzyl)-N-piperidin-4-yl-1H-benzimidazol-2-amine dihydrobromide

There total 14 articles about 1-(4-Fluorobenzyl)-N-piperidin-4-yl-1H-benzimidazol-2-amine dihydrobromide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 84501-68-8
ethyl 4-[[1-[(4-fluorophenyl)methyl]-1H-benzimidazol-2-yl]amino]-1-piperidinecarboxylate

: 75970-64-8
1-[(4-fluorophenyl)methyl]-N-(4-piperidinyl)-1H-benzimidazol-2-amine dihydrobromide

Guidance literature:: With hydrogen bromide; for 1h; Heating;
DOI:10.1080/00397919608004642

Reference yield:

: 73734-07-3
(1H-benzimidazol-2-yl)-(1-ethoxycarbonyl-piperidin-4-yl)amine

: 75970-64-8
1-[(4-fluorophenyl)methyl]-N-(4-piperidinyl)-1H-benzimidazol-2-amine dihydrobromide

Guidance literature:: Multi-step reaction with 2 steps

1: 40 percent / sodium carbonate, potassium iodide / dimethylformamide / 70 °C

2: 82 percent / 48 percent hydrobromic acid / 1 h / Heating

With hydrogen bromide; sodium carbonate; potassium iodide; In N,N-dimethyl-formamide;
DOI:10.1021/jm00150a029

Reference yield:

: 352-11-4
1-chloromethyl-4-fluorobenzene

: 75970-64-8
1-[(4-fluorophenyl)methyl]-N-(4-piperidinyl)-1H-benzimidazol-2-amine dihydrobromide

Guidance literature:: Multi-step reaction with 2 steps

1: 40 percent / sodium carbonate, potassium iodide / dimethylformamide / 70 °C

2: 82 percent / 48 percent hydrobromic acid / 1 h / Heating

With hydrogen bromide; sodium carbonate; potassium iodide; In N,N-dimethyl-formamide;
DOI:10.1021/jm00150a029