3-[5-Formyl-4-methyl-1-(toluene-4-sulfonyl)-1H-pyrrol-3-yl]-propionitrile

Base Information

• Chemical Name: 3-[5-Formyl-4-methyl-1-(toluene-4-sulfonyl)-1H-pyrrol-3-yl]-propionitrile
• CAS No.: 180283-46-9
• Molecular Formula: C₁₆H₁₆N₂O₃S
• Molecular Weight: 316.381
• Mol file: 180283-46-9.mol

Synonyms:3-[5-Formyl-4-methyl-1-(toluene-4-sulfonyl)-1H-pyrrol-3-yl]-propionitrile

Chemical Property of 3-[5-Formyl-4-methyl-1-(toluene-4-sulfonyl)-1H-pyrrol-3-yl]-propionitrile

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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Technology Process of 3-[5-Formyl-4-methyl-1-(toluene-4-sulfonyl)-1H-pyrrol-3-yl]-propionitrile

There total 4 articles about 3-[5-Formyl-4-methyl-1-(toluene-4-sulfonyl)-1H-pyrrol-3-yl]-propionitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(E,E)-hexa-2,4-dienenitrile (35684-10-7) → 3-[5-Formyl-4-methyl-1-(toluene-4-sulfonyl)-1H-pyrrol-3-yl]-propionitrile (180283-46-9)

Guidance literature:

Multi-step reaction with 4 steps

1: NaH / diethyl ether; dimethylsulfoxide / 2 h / 0 °C

2: H₂ / 5percent Pd/C / ethyl acetate / 20 h

3: 57 percent / POCl₃ / CH₂Cl₂ / 1 h / 0 °C

4: 1.) NaH / 1.) THF, RT, 1 h, 2.) THF, 16 h

With hydrogen; sodium hydride; trichlorophosphate; palladium on activated charcoal; In diethyl ether; dichloromethane; dimethyl sulfoxide; ethyl acetate;

DOI:10.1055/s-1996-4308

Reference yield:

(E)-3-(4-Methyl-1H-pyrrol-3-yl)-acrylonitrile → 3-[5-Formyl-4-methyl-1-(toluene-4-sulfonyl)-1H-pyrrol-3-yl]-propionitrile (180283-46-9)

Guidance literature:

Multi-step reaction with 3 steps

1: H₂ / 5percent Pd/C / ethyl acetate / 20 h

2: 57 percent / POCl₃ / CH₂Cl₂ / 1 h / 0 °C

3: 1.) NaH / 1.) THF, RT, 1 h, 2.) THF, 16 h

With hydrogen; sodium hydride; trichlorophosphate; palladium on activated charcoal; In dichloromethane; ethyl acetate;

DOI:10.1055/s-1996-4308

Reference yield:

3-(4-Methyl-1H-pyrrol-3-yl)-propionitrile (180283-42-5) → 3-[5-Formyl-4-methyl-1-(toluene-4-sulfonyl)-1H-pyrrol-3-yl]-propionitrile (180283-46-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 57 percent / POCl₃ / CH₂Cl₂ / 1 h / 0 °C

2: 1.) NaH / 1.) THF, RT, 1 h, 2.) THF, 16 h

With sodium hydride; trichlorophosphate; In dichloromethane;

DOI:10.1055/s-1996-4308

upstream raw materials:

p-toluenesulfonyl chloride

3-(5-Formyl-4-methyl-1H-pyrrol-3-yl)-propionitrile

(E,E)-hexa-2,4-dienenitrile

3-(4-Methyl-1H-pyrrol-3-yl)-propionitrile