Technology Process of 5-phenyl-2,3,4,7-tetrahydrothiepine 1,1-dioxide
There total 5 articles about 5-phenyl-2,3,4,7-tetrahydrothiepine 1,1-dioxide which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
3-chloro-benzenecarboperoxoic acid;
In
dichloromethane;
at 0 ℃;
for 2h;
DOI:10.1021/ja306731u
- Guidance literature:
-
Multi-step reaction with 2 steps
1: hydrogenchloride; water / methanol / 20 °C / Inert atmosphere
2: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 2 h / 0 °C
With
hydrogenchloride; water; 3-chloro-benzenecarboperoxoic acid;
In
methanol; dichloromethane;
DOI:10.1021/ja306731u
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: water; lithium chloride / dimethyl sulfoxide / 5 h / 185 °C / Inert atmosphere
2.1: cerium(III) chloride / tetrahydrofuran; diethyl ether / 0 °C / Inert atmosphere
2.2: 0 - 20 °C / Inert atmosphere
2.3: Inert atmosphere; Large scale reaction
3.1: hydrogenchloride; water / methanol / 20 °C / Inert atmosphere
4.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 2 h / 0 °C
With
hydrogenchloride; cerium(III) chloride; water; 3-chloro-benzenecarboperoxoic acid; lithium chloride;
In
tetrahydrofuran; methanol; diethyl ether; dichloromethane; dimethyl sulfoxide;
DOI:10.1021/ja306731u
