4-(2-methylthiazol-4-yl)-N-(3,3,3-trifluoropropyl)benzamide

Base Information

• Chemical Name: 4-(2-methylthiazol-4-yl)-N-(3,3,3-trifluoropropyl)benzamide
• CAS No.: 1589818-98-3
• Molecular Formula: C₁₄H₁₃F₃N₂OS
• Molecular Weight: 314.331
• Mol file: 1589818-98-3.mol

Synonyms:4-(2-methylthiazol-4-yl)-N-(3,3,3-trifluoropropyl)benzamide

Chemical Property of 4-(2-methylthiazol-4-yl)-N-(3,3,3-trifluoropropyl)benzamide

Chemical Property:

Purity/Quality:

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Technology Process of 4-(2-methylthiazol-4-yl)-N-(3,3,3-trifluoropropyl)benzamide

There total 1 articles about 4-(2-methylthiazol-4-yl)-N-(3,3,3-trifluoropropyl)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

4-(2-methylthiazol-4-yl)benzoic acid (294620-60-3) + (3,3,3-trifluoropropyl)amine hydrochloride (2968-33-4) → 4-(2-methylthiazol-4-yl)-N-(3,3,3-trifluoropropyl)benzamide (1589818-98-3)

Guidance literature:

With benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃; for 2h;

DOI:10.1021/jm500422b

Reference yield: 61.0%

4-(2-methylthiazol-4-yl)-N-(3,3,3-trifluoropropyl)benzamide (1589818-98-3) + chloromethyl methyl ether (107-30-2) → N-(methoxymethyl)-4-(2-methyl-1,3-thiazol-4-yl)-N-(3,3,3-trifluoropropyl)benzamide

Guidance literature:

4-(2-methylthiazol-4-yl)-N-(3,3,3-trifluoropropyl)benzamide; With potassium tert-butylate; tetra(n-butyl)ammonium hydrogensulfate; In tetrahydrofuran; for 0.25h; Inert atmosphere;

chloromethyl methyl ether; In tetrahydrofuran; at 20 ℃; for 0.0833333h; Inert atmosphere;

DOI:10.1039/c9ob00680j

Reference yield: 16.0%

4-(2-methylthiazol-4-yl)-N-(3,3,3-trifluoropropyl)benzamide (1589818-98-3) → 4-(5-fluoro-2-methylthiazol-4-yl)-N-(3,3,3-trifluoropropyl)benzamide

Guidance literature:

With Selectfluor; In N,N-dimethyl-formamide; at 0 - 20 ℃; for 55h;

DOI:10.1021/acsinfecdis.9b00277

upstream raw materials:

4-(2-methylthiazol-4-yl)benzoic acid

(3,3,3-trifluoropropyl)amine hydrochloride